ID G9DCX3_HETGA Unreviewed; 1884 AA.
AC G9DCX3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN Name=SCN9A {ECO:0000313|EMBL:AEV53348.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:AEV53348.1};
RN [1] {ECO:0000313|EMBL:AEV53348.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22174253; DOI=10.1126/science.1213760;
RA Smith E.S.J., Omerbasic D., Anirudhan G., Lechner S.G., Lapatsina L.,
RA Lewin G.R.;
RT "The molecular basis of acid insensitivity in the African naked mole-rat.";
RL Science 334:1557-1560(2011).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; JF912494; AEV53348.1; -; mRNA.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF221; SODIUM CHANNEL PROTEIN TYPE 9 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 358..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 717..743
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 755..773
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 793..814
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 835..863
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 925..948
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1173..1191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1212..1228
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1240..1260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1289..1315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1414..1437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1496..1514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1526..1544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1556..1576
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1613..1641
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1717..1740
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 105..390
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 515..674
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 724..955
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 962..1167
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1171..1446
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1495..1750
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 382..420
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEV53348.1"
FT NON_TER 1884
FT /evidence="ECO:0000313|EMBL:AEV53348.1"
SQ SEQUENCE 1884 AA; 214652 MW; 6395DBE2F8D4E58E CRC64;
AHIEQRIAER KAQEPKEEKK DDDEEGPKPS RDLEAGKQLP FIYGDIPPGM VSEALEDLDP
YYADKKTFIV LNKGKAIFRF NATPALYILS PFSPLRRISI KILVHSLFSM LIMCTILTNC
IFMTMSSPPE WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
VTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI LTVFCLSVFA
LIGLQLFMGN LRHKCVQLEF AENETAISAL DNFENKEDLK KYVYYLEGSK DALLCGFSTD
SGQCPEGYKC VKLGRNPDYG YTSFDTFSWA FLALFRLMTQ DYWENLYQQT LRAAGKTYMI
FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE LEFQQMLDQL KREQEEAEAI
AVAAAEYTSI GRSQIMGLSE SSSETSKLSS KSGKERRNRR KKKNQKKLSS GEEKRDDEKL
FKSESDGRVR RKKFFLGVEG PRQAREKRLF TPNQSPLSIR GSLFFSRGSS RTSFFSFKGG
GKNIGFENEF ADDEHSIFGG NESRRGSLFL PPRFRERRSS NISQASRSPP MLPVNGKMHS
AVDCNGVVSL VDGPSALMLP NGQLLPEVII DKATSDDSGT TIQIRKKRCS SSYFLSEDML
NDPHVRQRAM SRASILTNTV EELEESRQKC PPWWYRFAHT FLIWNCSPYW IKFKKFIYFI
VMDPFVDLAI TICIVLNTLF MAMEHHPMTL EFKNVLSVGN LVFTGIFAAE MVLKLIAMDP
YEYFQVGWNI FDSLIVTLSL VELFLSHVEG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG
NSMGALGNLT LVLAIIVFIF AVVGMQLFGK SYKECVCKIN EDCTLPRWHM NDFFHSFLIV
FRVLCGEWIE TMWDCMEVAG QAMCLIVYMM VMVIGNLVVL NLFLALLLSS FSSDNLTAIE
DDPDANNLQI AVARIKKGID YVKQTAREFI LKAFSKKPKV PQVVRQVEDL NSKKENCISN
HTLAEMSKDS HFHKENEKSS GFESSVDRNL VEESDYQSFI HNPSLTVIVP IAPGESDLEN
MNTEELSSDS DSDYSKERLN RSSSSECSTV DNPVPGEGEE AESEPVNSDE PEACFTDGCV
RRFPCCQVSI ESGKGKIWWN IRKTCYRIVE HSWFESFIVL MILLSSGALA FEDIYIEKKK
TIKIILEYAD KIFTYIFILE MLLKWVAYGY KTYFTNAWCW LDFLIVDVSV VTLVASTLGY
SDLGPIKSLR TLRALRPLRA LSRFEGMRVV VNALIGAIPS IMNVLLVCLI FWLIFSIMGV
NLFAGKFYEC VNTTDGLRFL DSQVHNRSEC FALMNVTSDV RWKNLKVNFD NVGLGYLSLL
QVATFKGWMD IMYAAVDSVN EDQQPRYEYN LYMYIYFVIF IIFGSFFTLN LFIGVIIDNF
NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP GNKFQGCIFD LVTNQAFDIT
IMVLICLNMV TMMVEKEGQS DEMINVLYWI NVVFIILFTG ECVLKLISLR HYYFTVGWNI
FDFVVVILSI VGMFLAELIE KYFVSPTLFR VIRLARIGRI LRLIKGAKGI RTLLFALMMS
LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KEAGIDDMFN FETFGNSMIC LFQITTSAGW
DGLLAPILNS GPPDCDPEKE HPGSSVKGDC GNPSVGIFYF VSYIIISFLV VVNMYIAVIL
ENFSVATEES TEPLSEDDFE MFYEVWEKFD PDATQFIEYS KLSDFAAALD PPLLIAKPNK
VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL GESGEMDSLR SQMEERFMSA NPSKVSYEPI
TTTLKRKQED VSATVIQRAY RHYR
//
