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Database: UniProt
Entry: G9EUQ9_9GAMM
LinkDB: G9EUQ9_9GAMM
Original site: G9EUQ9_9GAMM 
ID   G9EUQ9_9GAMM            Unreviewed;       206 AA.
AC   G9EUQ9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Dephospho-CoA kinase {ECO:0000256|HAMAP-Rule:MF_00376};
DE            EC=2.7.1.24 {ECO:0000256|HAMAP-Rule:MF_00376};
DE   AltName: Full=Dephosphocoenzyme A kinase {ECO:0000256|HAMAP-Rule:MF_00376};
GN   Name=coaE {ECO:0000256|HAMAP-Rule:MF_00376};
GN   ORFNames=LDG_9058 {ECO:0000313|EMBL:EHL29059.1};
OS   Legionella drancourtii LLAP12.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=658187 {ECO:0000313|EMBL:EHL29059.1, ECO:0000313|Proteomes:UP000002770};
RN   [1] {ECO:0000313|EMBL:EHL29059.1, ECO:0000313|Proteomes:UP000002770}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LLAP12 {ECO:0000313|EMBL:EHL29059.1,
RC   ECO:0000313|Proteomes:UP000002770};
RX   PubMed=22047552; DOI=10.1186/1471-2164-12-542;
RA   Gimenez G., Bertelli C., Moliner C., Robert C., Raoult D., Fournier P.E.,
RA   Greub G.;
RT   "Insight into cross-talk between intra-amoebal pathogens.";
RL   BMC Genomics 12:542-542(2011).
CC   -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC       dephosphocoenzyme A to form coenzyme A. {ECO:0000256|HAMAP-
CC       Rule:MF_00376}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC         Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC         EC=2.7.1.24; Evidence={ECO:0000256|HAMAP-Rule:MF_00376};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 5/5. {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000256|ARBA:ARBA00009018,
CC       ECO:0000256|HAMAP-Rule:MF_00376}.
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DR   EMBL; JH413850; EHL29059.1; -; Genomic_DNA.
DR   RefSeq; WP_006872913.1; NZ_JH413850.1.
DR   AlphaFoldDB; G9EUQ9; -.
DR   STRING; 658187.LDG_9058; -.
DR   eggNOG; COG0237; Bacteria.
DR   HOGENOM; CLU_057180_1_2_6; -.
DR   InParanoid; G9EUQ9; -.
DR   OrthoDB; 9812943at2; -.
DR   UniPathway; UPA00241; UER00356.
DR   Proteomes; UP000002770; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02022; DPCK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF46; DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00376};
KW   Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00376, ECO:0000313|EMBL:EHL29059.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Reference proteome {ECO:0000313|Proteomes:UP000002770};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00376}.
FT   BINDING         12..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00376"
SQ   SEQUENCE   206 AA;  23316 MW;  0057576D8F52715F CRC64;
     MVYCVGLTGG IASGKSTVAE LFSELGIQVI YADKISKALT AKDQEAYMQI VTHYGTEILT
     DDGTLNRRKL RSIIFSDAKE RFWLEQLLHP LIRQKIKEQV DSSITPYCIV EIPLLIDKEK
     YPYINRILLV NAPIETQIAR VIQRDQCTRE QALAILAAQP GLNLRLKEAD DVLMNNLGFN
     ELKIAVNDLH HNYLQKALMS GFSRVN
//
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