ID G9FK54_PROJR Unreviewed; 694 AA.
AC G9FK54;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000256|ARBA:ARBA00015942};
DE AltName: Full=Osm-9-like TRP channel 1 {ECO:0000256|ARBA:ARBA00033256};
DE AltName: Full=Vanilloid receptor 1 {ECO:0000256|ARBA:ARBA00031766};
DE Flags: Fragment;
GN Name=TRPV1 {ECO:0000313|EMBL:AEW26681.1};
OS Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX NCBI_TaxID=242841 {ECO:0000313|EMBL:AEW26681.1};
RN [1] {ECO:0000313|EMBL:AEW26681.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CHYMTF {ECO:0000313|EMBL:AEW26681.1};
RX PubMed=22163322; DOI=10.1371/journal.pone.0028644;
RA Geng J., Liang D., Jiang K., Zhang P.;
RT "Molecular Evolution of the Infrared Sensory Gene TRPA1 in Snakes and
RT Implications for Functional Studies.";
RL PLoS ONE 6:E28644-E28644(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, dendritic spine membrane {ECO:0000256|ARBA:ARBA00004332};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004332}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV
CC subfamily. TRPV1 sub-subfamily. {ECO:0000256|ARBA:ARBA00010374}.
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DR EMBL; JN164349; AEW26681.1; -; mRNA.
DR AlphaFoldDB; G9FK54; -.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR InterPro; IPR008348; TrpV4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF17; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR PRINTS; PR01769; VRL2RECEPTOR.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000313|EMBL:AEW26681.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 451..630
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEW26681.1"
FT NON_TER 694
FT /evidence="ECO:0000313|EMBL:AEW26681.1"
SQ SEQUENCE 694 AA; 79719 MW; E16A7999022B17B5 CRC64;
SFYHMEQLAS NPIIKFSLSL ERGRCGDHCP KLLSTASIGV CAGKAFKLYD RRSLFDAVAQ
GDPSQLDDLL IFLLESLKIL TDAEFKEPDT GKTCLLKAML NLHNGRNDTI PVLLEIAEKT
ENLKEFVNTG YTDSYYRGQT ALHIAIERRN MYLVNLLVKN GADVHARAHG EFFQKIKGKP
GFYFGELPLS LAACTNQLNI VKYLLENPYQ PANIAEQDSM GNTVLHALVE IADNTADNTK
FVTRMYNDML ILGARINPTL RLEEVANRRG LTPLTLAAKM GKIQVFAYIL RREMKESECR
HLSRKFTEWA YGPVHSSLYD LSSIDTCEKN SVLEIIAYSS ETPDRHEMLL VEPLNQLLQD
KWDRFVKHLF YFNFFTYTVH ILILTVAAYY RPTKKEGTPP FTFRHTRGEY FRVTGEILSV
LGGAYFFFRG IKYFQQRRPS LKAIFTECYS ELLFFVHSLL LLGSAVLYFS RQEVYVVLMV
FALALGWSNL LYYTRGFQQM GIYSVMLEKM MLRDLGRFIM VYLLFHLGFS TAVVTLIEED
NEGRPETAQP AGVCPCPVRA RPSYNNLYTT CLELFKFTIG MGDLEFTENY HFKSIFIILL
LIYVVLTYIL LPNMLIALMG ETVNKIAQES KSIWKLQRTI TILNIENSYW NCIVNSFRSG
KRVLVGTTPD GKDDYRWCFR VDEVNWSTWN TNLS
//
