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Database: UniProt
Entry: G9FRL3_PROST
LinkDB: G9FRL3_PROST
Original site: G9FRL3_PROST 
ID   G9FRL3_PROST            Unreviewed;       263 AA.
AC   G9FRL3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA1 {ECO:0000313|EMBL:AEW26716.1};
OS   Providencia stuartii.
OG   Plasmid IncA/C {ECO:0000313|EMBL:AEW26716.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Providencia.
OX   NCBI_TaxID=588 {ECO:0000313|EMBL:AEW26716.1};
RN   [1] {ECO:0000313|EMBL:AEW26716.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PsB/3 {ECO:0000313|EMBL:AEW26716.1};
RC   PLASMID=IncA/C {ECO:0000313|EMBL:AEW26716.1};
RX   PubMed=22155825; DOI=10.1128/AAC.05267-11;
RA   Arpin C., Thabet L., Yassine H., Messadi A.A., Boukadida J., Dubois V.,
RA   Coulange-Mayonnove L., Andre C., Quentin C.;
RT   "Evolution of an Incompatibility Group IncA/C Plasmid Harboring blaCMY-16
RT   and qnrA6 Genes and Its Transfer through Three Clones of Providencia
RT   stuartii during a Two-Year Outbreak in a Tunisian Burn Unit.";
RL   Antimicrob. Agents Chemother. 56:1342-1349(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; JN193567; AEW26716.1; -; Genomic_DNA.
DR   RefSeq; WP_001209508.1; NZ_JALLDV010000066.1.
DR   RefSeq; YP_005351816.1; NC_016974.1.
DR   AlphaFoldDB; G9FRL3; -.
DR   OMA; VRPWRYP; -.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819};
KW   Plasmid {ECO:0000313|EMBL:AEW26716.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819}.
FT   DOMAIN          28..76
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          152..254
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   263 AA;  29360 MW;  1E9EAC8CDA103FDF CRC64;
     MREVVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
     TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
     GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEEDRLA
     SRADQLEEFV HYVKGEITKV VGK
//
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