ID G9I9A4_KLEPN Unreviewed; 144 AA.
AC G9I9A4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=UmuD {ECO:0000313|EMBL:ALU64664.1, ECO:0000313|EMBL:SMY31134.1};
DE SubName: Full=MucA {ECO:0000313|EMBL:AEV46202.1};
DE SubName: Full=Protein impA {ECO:0000313|EMBL:AKJ18675.1};
DE SubName: Full=UmnD {ECO:0000313|EMBL:SYH37477.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:SYH37477.1};
GN Name=mucA {ECO:0000313|EMBL:AEV46202.1};
GN Synonyms=umuD {ECO:0000313|EMBL:ALU64664.1}, umuD_3
GN {ECO:0000313|EMBL:SYH37477.1};
GN ORFNames=BB784_30760 {ECO:0000313|EMBL:APP56261.1}, KPE71T_00080
GN {ECO:0000313|EMBL:AGW25503.1}, PKLPN57_72
GN {ECO:0000313|EMBL:SMY31134.1}, SAMEA3515122_05022
GN {ECO:0000313|EMBL:SYH37477.1};
OS Klebsiella pneumoniae.
OG Plasmid 2964TF {ECO:0000313|EMBL:ALU64891.1},
OG Plasmid 6411TF {ECO:0000313|EMBL:ALU64664.1},
OG Plasmid pFOX-7a {ECO:0000313|EMBL:CDN24835.1},
OG Plasmid pJEG011 {ECO:0000313|EMBL:AGJ73909.1},
OG Plasmid pKP112 {ECO:0000313|EMBL:CRN12902.1},
OG Plasmid pKPoxa-48N1 {ECO:0000313|EMBL:AGL12975.1},
OG Plasmid pKPoxa-48N2 {ECO:0000313|EMBL:AGL13049.1},
OG Plasmid pKp_Goe_024-3 {ECO:0000313|EMBL:APP56261.1},
OG Plasmid pKpn-E1.Nr7 {ECO:0000313|EMBL:AKA86740.1},
OG Plasmid pOXA-48 {ECO:0000313|EMBL:AEV46202.1},
OG Plasmid pOXA-48E1 {ECO:0000313|EMBL:AKJ18675.1},
OG Plasmid pkp_goe_024-3 {ECO:0000313|Proteomes:UP000184679}, and
OG Plasmid unnamed {ECO:0000313|EMBL:AGW25503.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:AEV46202.1};
RN [1] {ECO:0000313|EMBL:AEV46202.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kp11978 {ECO:0000313|EMBL:AEV46202.1};
RC PLASMID=pOXA-48 {ECO:0000313|EMBL:AEV46202.1};
RX PubMed=22083465; DOI=10.1128/AAC.05289-11;
RA Poirel L., Bonnin R.A., Nordmann P.;
RT "Genetic Features of the Widespread Plasmid Coding for the Carbapenemase
RT OXA-48.";
RL Antimicrob. Agents Chemother. 56:559-562(2012).
RN [2] {ECO:0000313|EMBL:AGW25503.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E71T {ECO:0000313|EMBL:AGW25503.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:AGW25503.1};
RA Power K.A., Wang J., Karczmarczyk M., Crowley B., Fanning S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AGL12975.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pKPoxa-48N1 {ECO:0000313|EMBL:AGL12975.1}, and pKPoxa-48N2
RC {ECO:0000313|EMBL:AGL13049.1};
RX PubMed=23733457; DOI=10.1128/AAC.02550-12;
RA Berger S., Alauzet C., Aissa N., Henard S., Rabaud C., Bonnet R.,
RA Lozniewski A.;
RT "Characterization of a New blaOXA-48-Carrying Plasmid in
RT Enterobacteriaceae.";
RL Antimicrob. Agents Chemother. 57:4064-4067(2013).
RN [4] {ECO:0000313|EMBL:AGJ73909.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kp002 {ECO:0000313|EMBL:AGJ73909.1};
RC PLASMID=pJEG011 {ECO:0000313|EMBL:AGJ73909.1};
RX PubMed=23555831;
RA Espedido B.A., Steen J.A., Ziochos H., Grimmond S.M., Cooper M.A.,
RA Gosbell I.B., van Hal S.J., Jensen S.O.;
RT "Whole Genome Sequence Analysis of the First Australian OXA-48-Producing
RT Outbreak-Associated Klebsiella pneumoniae Isolates: The Resistome and In
RT Vivo Evolution.";
RL PLoS ONE 8:E59920-E59920(2013).
RN [5] {ECO:0000313|EMBL:CDN24835.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=45A03 {ECO:0000313|EMBL:CDN24835.1};
RC PLASMID=pFOX-7a {ECO:0000313|EMBL:CDN24835.1};
RX PubMed=24928855; DOI=10.1093/jac/dku216;
RA Di Pilato V., Arena F., Giani T., Conte V., Cresti S., Rossolini G.M.;
RT "Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the
RT FOX-7 AmpC-type ?-lactamase, involved in a large outbreak in a neonatal
RT intensive care unit.";
RL J. Antimicrob. Chemother. 69:2620-2624(2014).
RN [6] {ECO:0000313|EMBL:AGW25503.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E71T {ECO:0000313|EMBL:AGW25503.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:AGW25503.1};
RX PubMed=24520822; DOI=10.1089/mdr.2013.0022;
RA Power K., Wang J., Karczmarczyk M., Crowley B., Cotter M., Haughton P.,
RA Lynch M., Schaffer K., Fanning S.;
RT "Molecular Analysis of OXA-48-Carrying Conjugative IncL/M-Like Plasmids in
RT Clinical Isolates of Klebsiella pneumoniae in Ireland.";
RL Microb. Drug Resist. 20:270-274(2014).
RN [7] {ECO:0000313|EMBL:AKA86740.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kpn-E1.Nr7 {ECO:0000313|EMBL:AKA86740.1};
RC PLASMID=pKpn-E1.Nr7 {ECO:0000313|EMBL:AKA86740.1};
RX PubMed=25933288;
RA Carattoli A., Seiffert S.N., Schwendener S., Perreten V., Endimiani A.;
RT "Differentiation of IncL and IncM Plasmids Associated with the Spread of
RT Clinically Relevant Antimicrobial Resistance.";
RL PLoS ONE 10:E0123063-E0123063(2015).
RN [8] {ECO:0000313|EMBL:AKJ18675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=153877-1 {ECO:0000313|EMBL:AKJ18675.1};
RC PLASMID=pOXA-48E1 {ECO:0000313|EMBL:AKJ18675.1};
RA Nijhuis R., Kant A., Mevius D., Bossers A.;
RT "Characterization of plasmids in two different OXA-48 carbapenemase
RT positive isolates from one patient.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:CRN12902.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KP112 {ECO:0000313|EMBL:CRN12902.1};
RC PLASMID=pKP112 {ECO:0000313|EMBL:CRN12902.1};
RA Racha B.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:CRN12902.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KP112 {ECO:0000313|EMBL:CRN12902.1};
RC PLASMID=pKP112 {ECO:0000313|EMBL:CRN12902.1};
RA Beyrouthy R., Hamze M., Bonnet R.;
RT "Plasmid pKP112.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:ALU64664.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kp2964 {ECO:0000313|EMBL:ALU64891.1}, and Kp6411
RC {ECO:0000313|EMBL:ALU64664.1};
RC PLASMID=2964TF {ECO:0000313|EMBL:ALU64891.1}, and 6411TF
RC {ECO:0000313|EMBL:ALU64664.1};
RA Bueno M.F.C., Francisco G.R., Doi Y., Garcia D.O.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:ALU64664.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kp2964 {ECO:0000313|EMBL:ALU64891.1}, and Kp6411
RC {ECO:0000313|EMBL:ALU64664.1};
RC PLASMID=2964TF {ECO:0000313|EMBL:ALU64891.1}, and 6411TF
RC {ECO:0000313|EMBL:ALU64664.1};
RX PubMed=26729503; DOI=10.1128/AAC.02562-15;
RA Bueno M.F., Francisco G.R., de Oliveira Garcia D., Doi Y.;
RT "Complete Sequences of Multidrug Resistance Plasmids Bearing rmtD1 and
RT rmtD2 16S rRNA Methyltransferase Genes.";
RL Antimicrob. Agents Chemother. 60:1928-1931(2016).
RN [13] {ECO:0000313|EMBL:APP56261.1, ECO:0000313|Proteomes:UP000184679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kp_Goe_827024 {ECO:0000313|EMBL:APP56261.1,
RC ECO:0000313|Proteomes:UP000184679};
RC PLASMID=pkp_goe_024-3 {ECO:0000313|Proteomes:UP000184679}, and
RC pKp_Goe_024-3 {ECO:0000313|EMBL:APP56261.1};
RA Bohne W., Bunk B., Overmann J., Gross U., Zautner A.E.;
RT "A nosocomial outbreak of oxa48-expressing Klebsialla pneumoniae in Lower
RT Saxony.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:SMY31134.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Klebsiella pneumoniae KLPN57 {ECO:0000313|EMBL:SMY31134.1};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:SYH37477.1, ECO:0000313|Proteomes:UP000258673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EuSCAPE_IT093 {ECO:0000313|EMBL:SYH37477.1,
RC ECO:0000313|Proteomes:UP000258673};
RG Pathogen Informatics;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S24 family.
CC {ECO:0000256|ARBA:ARBA00007484, ECO:0000256|RuleBase:RU003991}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JN626286; AEV46202.1; -; Genomic_DNA.
DR EMBL; KC354801; AGJ73909.1; -; Genomic_DNA.
DR EMBL; KC757416; AGL12975.1; -; Genomic_DNA.
DR EMBL; KC757417; AGL13049.1; -; Genomic_DNA.
DR EMBL; KC335143; AGW25503.1; -; Genomic_DNA.
DR EMBL; KM406491; AKA86740.1; -; Genomic_DNA.
DR EMBL; KP659188; AKJ18675.1; -; Genomic_DNA.
DR EMBL; KT935445; ALU64664.1; -; Genomic_DNA.
DR EMBL; KT935446; ALU64891.1; -; Genomic_DNA.
DR EMBL; CP018706; APP56261.1; -; Genomic_DNA.
DR EMBL; HG934082; CDN24835.1; -; Genomic_DNA.
DR EMBL; LN864819; CRN12902.1; -; Genomic_DNA.
DR EMBL; LT882698; SMY31134.1; -; Genomic_DNA.
DR EMBL; UKUT01000018; SYH37477.1; -; Genomic_DNA.
DR RefSeq; WP_004187425.1; NZ_WYAL01000050.1.
DR RefSeq; YP_006958786.1; NC_019154.1.
DR RefSeq; YP_007878508.1; NC_021078.1.
DR RefSeq; YP_008090836.1; NC_021488.1.
DR RefSeq; YP_008110836.1; NC_021502.1.
DR RefSeq; YP_008888791.1; NC_023027.1.
DR RefSeq; YP_009067898.1; NC_025134.1.
DR MEROPS; S24.003; -.
DR GeneID; 83576059; -.
DR Proteomes; UP000184679; Plasmid pkp_goe_024-3.
DR Proteomes; UP000258673; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd06529; S24_LexA-like; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR039418; LexA-like.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR006197; Peptidase_S24_LexA.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR PANTHER; PTHR33516; LEXA REPRESSOR; 1.
DR PANTHER; PTHR33516:SF13; PROPHAGE REPRESSOR COHE-RELATED; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00726; LEXASERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813,
KW ECO:0000256|RuleBase:RU003991}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003991};
KW Plasmid {ECO:0000313|EMBL:AEV46202.1};
KW Protease {ECO:0000256|ARBA:ARBA00022825};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW SOS mutagenesis {ECO:0000256|ARBA:ARBA00023199};
KW SOS response {ECO:0000256|ARBA:ARBA00023236}.
FT DOMAIN 20..132
FT /note="Peptidase S24/S26A/S26B/S26C"
FT /evidence="ECO:0000259|Pfam:PF00717"
SQ SEQUENCE 144 AA; 16077 MW; 7494A385EF727ED0 CRC64;
MALDLVYPRP SVEGDALPFF AEPVAAGFPS PAAGYEANEL NLHDYCVRRP AATYFLRVSG
DSMRDARIHD GDVLVVDRAE EPRHGSIVIA SIDNEFTVKQ LQLRPYPCLM PLNPAFPPIR
FDPEALQIWG VVTFTVMRHR PCTP
//
