ID G9K469_MUSPF Unreviewed; 405 AA.
AC G9K469;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein {ECO:0000256|ARBA:ARBA00040901};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AER99693.1};
RN [1] {ECO:0000313|EMBL:AER99693.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AER99693.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC pathway. {ECO:0000256|ARBA:ARBA00037579}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; JP011096; AER99693.1; -; mRNA.
DR AlphaFoldDB; G9K469; -.
DR HOGENOM; CLU_058243_0_0_1; -.
DR OMA; TQYMQLM; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd17119; Ubl_HERP2; 1.
DR InterPro; IPR039751; HERPUD1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12943:SF5; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN; 1.
DR PANTHER; PTHR12943; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..71
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 86..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AER99693.1"
FT NON_TER 405
FT /evidence="ECO:0000313|EMBL:AER99693.1"
SQ SEQUENCE 405 AA; 44879 MW; 13E34074084A8B30 CRC64;
MDQNGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTT RESHEALASS SSSSSDQSGS
TTPSSSQETL SLAASSSSEG LRQRTLPQAQ TDPAQSHQFP YVMQGNVDNQ LPGQAIPAGF
PVYPAFSPLQ MLWWQQLYAH QYYMQYQAAV SAQATSNANP TQPAASQPLN LAHVPGEEPP
PAPNLVAQEN RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
RFIMVMGAML LVYLHQAGWF PFRQEGGQQQ APNNNAEVNN DGQNANNLEL EEMERLMDDG
LEDESGEDAG EDASAVQRPG LMASAWSFIT TFFTSLIPEG PPQVA
//
