ID G9K8N8_MUSPF Unreviewed; 438 AA.
AC G9K8N8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Leucine rich repeat containing 17 {ECO:0000313|EMBL:AES01263.1, ECO:0000313|Ensembl:ENSMPUP00000018161.1};
DE SubName: Full=Leucine-rich repeat-containing protein 17 isoform X1 {ECO:0000313|RefSeq:XP_004739643.1, ECO:0000313|RefSeq:XP_012915912.1};
DE Flags: Fragment;
GN Name=LRRC17 {ECO:0000313|Ensembl:ENSMPUP00000018161.1,
GN ECO:0000313|RefSeq:XP_004739643.1, ECO:0000313|RefSeq:XP_012915912.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES01263.1};
RN [1] {ECO:0000313|EMBL:AES01263.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES01263.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
RN [2] {ECO:0000313|Ensembl:ENSMPUP00000018161.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004739643.1, ECO:0000313|RefSeq:XP_012915912.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004739643.1,
RC ECO:0000313|RefSeq:XP_012915912.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01005535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01005536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JP012665; AES01263.1; -; mRNA.
DR RefSeq; XP_004739643.1; XM_004739586.3.
DR RefSeq; XP_012915912.1; XM_013060458.2.
DR STRING; 9669.ENSMPUP00000018161; -.
DR Ensembl; ENSMPUT00000018427.1; ENSMPUP00000018161.1; ENSMPUG00000018275.1.
DR GeneID; 101692087; -.
DR KEGG; mpuf:101692087; -.
DR CTD; 10234; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000156400; -.
DR HOGENOM; CLU_049990_0_0_1; -.
DR OMA; RQTQECK; -.
DR OrthoDB; 5397338at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0048539; P:bone marrow development; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..438
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014092331"
FT DOMAIN 160..210
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 347..398
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 207..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES01263.1"
FT NON_TER 438
FT /evidence="ECO:0000313|EMBL:AES01263.1"
SQ SEQUENCE 438 AA; 52006 MW; 1D9DB87024F053C9 CRC64;
MRVVTVVILL FFCKAMELRK PSPRARANHG RAGGSRRGSS PVKRYAPGLP CEVYTYLHEK
YLDCQERRLV YVLPDWPQDL LHMLLARNKI RILKNKMFSK FKRLKSLDLQ QNEISKIEGE
AFFGLNKLTT LLLQHNQIKV LTEEVFIYTP LLSYLRLYDN PWHCTCEMET LISMLQIPRN
RNLGNYAKCE SPQELKNKKL RQLKPEQLCS EEESERLDPR PQVSRRPPVI KPEVDSSLCY
NYVFPIQTLD CKRKELKKVP NNIPPDIVKL DLSYNKINQL RPKEFEDVHE LKKLNLSSNG
IEFIDPAAFL GLTHLEELDL SNNSLQNFDY GVLEDLYFLK LLWLRDNPWR CDYNIHYLYY
WLKHHYNVHY NGLECKMPEE YKGWFVGKYI RTYFEECPKD KLPAYPETFD QDTEEDEWER
IHRDHAAKKQ SVRITILG
//
