ID G9KEK5_MUSPF Unreviewed; 305 AA.
AC G9KEK5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Mimecan {ECO:0000256|ARBA:ARBA00018423};
DE AltName: Full=Osteoglycin {ECO:0000256|ARBA:ARBA00031730};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES03330.1};
RN [1] {ECO:0000313|EMBL:AES03330.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES03330.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC beta-2. {ECO:0000256|ARBA:ARBA00003759}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class III subfamily. {ECO:0000256|ARBA:ARBA00006912}.
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DR EMBL; JP014732; AES03330.1; -; mRNA.
DR AlphaFoldDB; G9KEK5; -.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043547; Mimecan/Epiphycan/Opticin.
DR PANTHER; PTHR46269; EPIPHYCAN-RELATED; 1.
DR PANTHER; PTHR46269:SF1; MIMECAN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..305
FT /note="Mimecan"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003522953"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES03330.1"
FT NON_TER 305
FT /evidence="ECO:0000313|EMBL:AES03330.1"
SQ SEQUENCE 305 AA; 34920 MW; EED3051F08FA1FE0 CRC64;
PVTLIFAEMK TLQSTFLLLL LVPLIKPAPP TQHDSRMTYD YGTDSFEEAL FSQDFEDKYL
DGKNIKEKET MVIPKEKSLQ LQRDEHATPP PFKKENDEMP TCLLCVCLSG SVYCEEVDID
AVPPLPKESA YLYARFNKIK KLTAKDFAEI PNLRRLDFTG NLIEDIEDGT FSKLSLLEEL
TLAENQLLKL PVLPPKLTLF NAKYNKIKSR GIKANTFKKL NHLSFLYLDH NALESVPLNL
PESLRIIHLQ FNNITSITDD TFCKANDTRY IRDRIEEIRL EGNPIVLGKH PNSFICLKRL
PVGSY
//
