ID G9KF56_MUSPF Unreviewed; 606 AA.
AC G9KF56;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=3'-phosphoadenosine 5'-phosphosulfate synthase 2 {ECO:0000313|EMBL:AES03531.1};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES03531.1};
RN [1] {ECO:0000313|EMBL:AES03531.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES03531.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- PATHWAY: Sulfur metabolism; sulfate assimilation.
CC {ECO:0000256|ARBA:ARBA00005050}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the sulfate
CC adenylyltransferase family. {ECO:0000256|ARBA:ARBA00009290}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the APS kinase
CC family. {ECO:0000256|ARBA:ARBA00007268}.
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DR EMBL; JP014933; AES03531.1; -; mRNA.
DR AlphaFoldDB; G9KF56; -.
DR UniPathway; UPA00097; -.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000103; P:sulfate assimilation; IEA:UniProtKB-UniPathway.
DR CDD; cd02027; APSK; 1.
DR CDD; cd00517; ATPS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR InterPro; IPR002891; APS_kinase.
DR InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR024951; Sulfurylase_cat_dom.
DR InterPro; IPR002650; Sulphate_adenylyltransferase.
DR NCBIfam; TIGR00455; apsK; 1.
DR NCBIfam; TIGR00339; sopT; 1.
DR PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR PANTHER; PTHR11055:SF16; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2; 1.
DR Pfam; PF01583; APS_kinase; 1.
DR Pfam; PF01747; ATP-sulfurylase; 1.
DR Pfam; PF14306; PUA_2; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 208..370
FT /note="ATP-sulfurylase PUA-like"
FT /evidence="ECO:0000259|Pfam:PF14306"
FT DOMAIN 378..600
FT /note="Sulphate adenylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01747"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES03531.1"
FT NON_TER 606
FT /evidence="ECO:0000313|EMBL:AES03531.1"
SQ SEQUENCE 606 AA; 68584 MW; CE47BBA36655C3AE CRC64;
ESQQKSTNVV YQAHHVSRNK RGQVVGTRGG FRGCTVWLTG LSGAGKTTIS FALEEYLVSH
AIPCYSLDGD NVRHGLNKNL GFSPGDREEN IRRIAEVAKL FADAGLVCIT SFISPFTKDR
ENARKIHESA GLPFFEIFVD APLNICESRD VKGLYKRARA GEIKGFTGID SDYEKPETPE
RVLKTNLSSV SDCVQQVVEL LQEQNIVPHT IMKGVHELFV PENKLDQVRA EAEALPSLEI
TKLDLQWVQV LSEGWATPLK GFMREKEYLQ AIHFDTLLDD GVINMSIPIV LPVSTDDKTR
LEGRSEFVLT HGGRRVAVLR DPEFYQPYEH RKEERCSRVW GTMCAKHPHI KMVMESGDWL
VGGDLHVLER IRWNDGLDQY RLTPLELKQK CKEMNADAVF AFQLRNPVHN GHALLMQDTR
RRLLERGYKH PVLLLHPLGG WTKDDDVPLA WRMKQHAAVL EEGVLDPKST IVAIFPSPML
YAGPTEVQWH CRSRMIAGVN FYIVGRDPAG MPNPETKKDL YEPTHGGKVL SMAPGLTSVE
IIPFRVAAYN KAKKAMDFYD PARHNEFDFI SGTRMRKLAR EGENPPDGFM APKAWKVLTD
YYRSLE
//
