ID G9KFB0_MUSPF Unreviewed; 376 AA.
AC G9KFB0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Pre-B-cell leukemia homeobox 2 {ECO:0000313|EMBL:AES03585.1};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES03585.1};
RN [1] {ECO:0000313|EMBL:AES03585.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES03585.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC {ECO:0000256|ARBA:ARBA00007601}.
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DR EMBL; JP014987; AES03585.1; -; mRNA.
DR AlphaFoldDB; G9KFB0; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005542; PBX_PBC_dom.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR PANTHER; PTHR11850:SF50; PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 25..220
FT /note="PBC"
FT /evidence="ECO:0000259|PROSITE:PS51978"
FT DOMAIN 219..282
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 221..283
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES03585.1"
FT NON_TER 376
FT /evidence="ECO:0000313|EMBL:AES03585.1"
SQ SEQUENCE 376 AA; 40612 MW; D20AAFF9013585CA CRC64;
EPGGPGEPPG GGDPGGGNGG VPGGRGKQDI GDILQQIMTI TDQSLDEAQA KKHALNCHRM
KPALFSVLCE IKEKTGLSIR SSQEEEPVDP QLMRLDNMLL AEGVAGPEKG GGSAAAAAAA
AASGGGVSPD NSIEHSDYRS KLAQIRHIYH SELEKYEQAC NEFTTHVMNL LREQSRTRPV
APKEMERMVS IIHRKFSAIQ MQLKQSTCEA VMILRSRFLD ARRKRRNFSK QATEVLNEYF
YSHLSNPYPS EEAKEELAKK CGITVSQVSN WFGNKRIRYK KNIGKFQEEA NIYAVKTAVS
VTQGGHSRTS SPTPPSSAGS GGSFNLSGSG DMFLGMPGLN GDSYSASQVE SLRHSMGPGG
YGDNLGGGQM YSPREM
//
