ID G9KGL1_MUSPF Unreviewed; 330 AA.
AC G9KGL1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Phosphoinositide-3-kinase, class 2, alpha polypeptide {ECO:0000313|EMBL:AES04036.1};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES04036.1};
RN [1] {ECO:0000313|EMBL:AES04036.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES04036.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; JP015438; AES04036.1; -; mRNA.
DR AlphaFoldDB; G9KGL1; -.
DR HOGENOM; CLU_002191_0_2_1; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF28; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 2: Evidence at transcript level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AES04036.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..189
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 257..330
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES04036.1"
FT NON_TER 330
FT /evidence="ECO:0000313|EMBL:AES04036.1"
SQ SEQUENCE 330 AA; 37573 MW; 8D834E8F2A31F311 CRC64;
YTTPQVDRSI IEQHNLETLE NDIKGKLLDI IHRDSSLGLS KEDKAFLWEK RYYCLKHPNS
LPKVLASAPN WKWVNLAKTY SLLQQWPPLN PLTALELLDS KFADQEVRSI AVTWIEAISD
DELTDLLPQF VQALKYEIYL NSSLVRFLLS RALGNIHIAH NLYWLLKDAL HDAQFGARYE
HVLGALLSVG GKGLREELLK QTKLVQLLGG VAEKVRQASG SARQVVLQRS MERVQSFFLR
NKCRLPLNPS LVAKELNIKS CSFFSSNAVP LKVTMLNADP MGDEINVMFK VGEDLRQDML
ALQMIKIMDK IWLKEGLDLR MVIFKCLSTG
//