ID G9KGT7_MUSPF Unreviewed; 325 AA.
AC G9KGT7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Polycystic kidney disease 1 {ECO:0000313|EMBL:AES04112.1};
DE Flags: Fragment;
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES04112.1};
RN [1] {ECO:0000313|EMBL:AES04112.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES04112.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JP015514; AES04112.1; -; mRNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..325
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003522788"
FT DOMAIN 1..132
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 180..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES04112.1"
FT NON_TER 325
FT /evidence="ECO:0000313|EMBL:AES04112.1"
SQ SEQUENCE 325 AA; 35244 MW; A2A4C062373B4AB7 CRC64;
AQLSAAARGL AASLLFLLLV KAAQQLRFVR QWSVFGKTLC RALPELAGAA LGLVALAAAY
TQLAVLLVSS CVDSIRSAAG ALLVLCPGSG GPALCPTESW RLSPLLCTGL WALRLWGALR
LGTVLLRWRY QALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR HKVRFEGMEP
LPSRSSRGSK ASPDAPPHSG GSDTSRPSTS SSQLDALSGG LGRLGPRGEP EPSRLQAVFE
ALLTQFDRLN QATEDVYQLE QRLQHLRGRG STGRPASPLH CVSSDPRRGX GWPCPAVWPG
PVEAWAWPLA PGGLPCGPRT RSTPA
//
