ID G9LPQ9_HELAM Unreviewed; 516 AA.
AC G9LPQ9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 28-JUN-2023, entry version 30.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=UGT41B2 {ECO:0000313|EMBL:AEW43132.1};
OS Helicoverpa armigera (Cotton bollworm) (Heliothis armigera).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Helicoverpa.
OX NCBI_TaxID=29058 {ECO:0000313|EMBL:AEW43132.1};
RN [1] {ECO:0000313|EMBL:AEW43132.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Toowoomba {ECO:0000313|EMBL:AEW43132.1};
RX PubMed=22155036; DOI=10.1016/j.ibmb.2011.11.006;
RA Ahn S.J., Vogel H., Heckel D.G.;
RT "Comparative analysis of the UDP-glycosyltransferase multigene family in
RT insects.";
RL Insect Biochem. Mol. Biol. 42:133-147(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; JQ070216; AEW43132.1; -; mRNA.
DR AlphaFoldDB; G9LPQ9; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF145; EG:EG0003.4 PROTEIN-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW Signal {ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 18..516
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5005133129"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 516 AA; 58186 MW; A605F0D340C9F7FC CRC64;
MKLPLAILLL CMSSTWAYKI LFVFPAATRS NDVLGKGVVW ALLKAGHEVT WAATYKQEAH
PNLTIIDLPE AKKIVDSFDP ITMADNNNIS MSFMKEHTVR ICTATAQNAE LRKVLVEKQF
DAVMTTFYLN EYDAGYAAIQ QVPWILFSTV NYHPMLELMV DEVRSIPTTP IVLMECETPM
SLPRRWLNGL MYMFLTAYNW YDQPNQVAQY ESMFSELAAK RGVPLPPFEE AKHNVSILLV
NSHESLQNGY SSPPNVVNIA GYHISEHLAP LPKDLQELMD KSKNGVIFFS MGSILRAAGL
DPKKRDALVK MFGKLPYTVI WKYEEPLDNL PPNVHIRPWL PQPTVLAHKN TVAFITHGGQ
SSTVEAIHAG MPVVVVPVGG DQPANAERAV RMGVALQVDY YKDTLADDLE VAVKELLGND
KYREKAKFLS KLFRTRPVPP AKLIPFYVEL AIETKGAYHL RSLSLKYSWY ERWMLDFVLA
VLGVLATLAW LVKLTVTACV RRFSGKKQSA NKKKKQ
//
