ID G9MX78_HYPVG Unreviewed; 1151 AA.
AC G9MX78;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHK21010.1};
GN ORFNames=TRIVIDRAFT_223476 {ECO:0000313|EMBL:EHK21010.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK21010.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK21010.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK21010.1}.
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DR EMBL; ABDF02000076; EHK21010.1; -; Genomic_DNA.
DR RefSeq; XP_013955203.1; XM_014099728.1.
DR AlphaFoldDB; G9MX78; -.
DR STRING; 413071.G9MX78; -.
DR EnsemblFungi; EHK21010; EHK21010; TRIVIDRAFT_223476.
DR GeneID; 25791772; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_223476; -.
DR eggNOG; KOG2070; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002632_0_0_1; -.
DR InParanoid; G9MX78; -.
DR OMA; WMEDQSD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 728..861
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 897..1134
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 90..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 128746 MW; BB17B5C7CE566C25 CRC64;
MDGVVGTAPP GSMYVRALYD YEADDRTSLS FHEGDVIQVI TQLESGWWDG VINGVRGWFP
SNYCQAITSP DEFPDVGQNG HANHHMEDDM EENELYEDSA DQDEDSEGEG FGSLPLEGTD
MGGDKSRADF WIPQATPDGR LFYYNMMTGD RSMELPLESP VSSAETGPRD RMNVAMPEKT
RPPPEMMARG LTQDEDDDSA TSASEAEGES LMLASRGSMP RIRGSFSAAL SPSTSMDSMN
GTSPARRKRS DAFGLGFANT SQPPNIASAT SFTSTTYNVP ATTSVPKSFF DDGSTPPLTW
SLLVTNMKRA IDRYREAVTN NARSEYVARA EDISDHLRLL LAAGSGTTDN HSGQPSIIST
NKALYPHFRD MMSKFSKLVI SSHIAAADWP NAESVQKCLQ EADGVLLGVF SYVEVARQQR
GEDIPRLFPG FVIGSTSGGS WQSNGLDYHD LMSPNFLDDE EGITEPTAVL DGNLLERLDE
HKRMLVSSIR ELEKNLTAPE KIIAPQRHEI IANNVCFAGG KVVETFRPWI AMIESVDLSS
LGNTFQTPQL EDFSINKQSL YDNIADLMLS CQAVAGPLAD EWSEVRGEPL ESRLDYVRQC
ARALETNSSH TGFSLQLLSE QVLINMQQQQ AKARQPPRGQ LQRGETMPYD RPHQRSDSRT
APVRPPLITT QSYSEGDAPP GFSRKGDYSK VKKIFGEDPS PQLQPDEDTP EFLLLDYEND
LSWDAKATTP TVKGGSLLAL VEQLTRHDKL DSSFNNTFLL TYRSFTSARE LFEMLVQRFG
IQPPEGLTQQ DYELWRDRKQ KLIRFRVVNI LKSWFDSFWM EEFNDESKTL IRDVYTFARD
TVKSTETPGS GPLMAILDQR LSGKEAGARR MIQTLNQSTP TPIIPKNMRK LKFLDIDVTE
FARQLTIIES RLYSKIKATE CLNKTWQKKV ADGDPDAAPN VKALILHSNQ MTNWVAEMIL
NQMDVKKRVV VIKHFVAVAD KCRGLNNFST LTSIISALGT APIARLKRTW DQVPQRTSAV
LETMRRLMAS TKNFGEYREA LHVANPPCIP FFGVYLTDLT FIEDGIPSVI KKTNLINFAK
RAKTAEVIRD IQQYQNVGYS LQPVPELQDY IVSNMQAAGD VHEMYDKSLQ IEPREREDEK
IVRVLAESGF L
//
