ID G9N388_HYPVG Unreviewed; 348 AA.
AC G9N388;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Ubiquitin-like 1-activating enzyme E1A {ECO:0000256|ARBA:ARBA00044354};
DE Flags: Fragment;
GN ORFNames=TRIVIDRAFT_23894 {ECO:0000313|EMBL:EHK18772.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK18772.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK18772.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK18772.1}.
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DR EMBL; ABDF02000085; EHK18772.1; -; Genomic_DNA.
DR RefSeq; XP_013952972.1; XM_014097497.1.
DR AlphaFoldDB; G9N388; -.
DR STRING; 413071.G9N388; -.
DR EnsemblFungi; EHK18772; EHK18772; TRIVIDRAFT_23894.
DR GeneID; 25792515; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_23894; -.
DR eggNOG; KOG2014; Eukaryota.
DR HOGENOM; CLU_002556_4_1_1; -.
DR InParanoid; G9N388; -.
DR OMA; EFFGQFD; -.
DR OrthoDB; 5483037at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0031510; C:SUMO activating enzyme complex; IEA:EnsemblFungi.
DR GO; GO:0019948; F:SUMO activating enzyme activity; IEA:EnsemblFungi.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:EnsemblFungi.
DR GO; GO:0016925; P:protein sumoylation; IEA:EnsemblFungi.
DR CDD; cd01492; Aos1_SUMO; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR PANTHER; PTHR10953:SF162; SUMO-ACTIVATING ENZYME SUBUNIT 1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 9..340
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHK18772.1"
FT NON_TER 348
FT /evidence="ECO:0000313|EMBL:EHK18772.1"
SQ SEQUENCE 348 AA; 38360 MW; F7924A3B2B8C9EF2 CRC64;
LSPDEIALYD RQIRLWGMAA QAKIQNANIL LITIRALANE IAKNLVLAGV GSLTVLDNAI
VTEADLGAQF LLSEVENPVG QNRAEAASAA LRKLNPRVQV HVDAEGVKAK GPSYFAGFDI
VIATDLDPDS FNLINTATRL NGKAFYAAGT HGMYGFIFSD LIEHDYVIER DLGNVATEPK
QETRTRSIVD VKTKKEGPKV IESVTKRELY STWFLASDVA SLPEEYTKSK RRLRSVSPTL
SCLRALWEFM QIQGGRLPGN REDLKLFTQI ATQKHKALSL PSETLKPEFL RSFLQNLGSE
IAPVTAILGG QLAQDVINVL GQKQQPIQNM VIFDGTTMEA LMYPLHPE
//
