ID G9NGB8_HYPAI Unreviewed; 873 AA.
AC G9NGB8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN ORFNames=TRIATDRAFT_81264 {ECO:0000313|EMBL:EHK50330.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK50330.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK50330.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK50330.1}.
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DR EMBL; ABDG02000014; EHK50330.1; -; Genomic_DNA.
DR RefSeq; XP_013948505.1; XM_014093030.1.
DR AlphaFoldDB; G9NGB8; -.
DR STRING; 452589.G9NGB8; -.
DR GeneID; 25785576; -.
DR eggNOG; KOG4266; Eukaryota.
DR HOGENOM; CLU_014424_0_0_1; -.
DR OMA; GHAYPAR; -.
DR OrthoDB; 2247221at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00306; Peptidases_S8_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000005426};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 790..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..832
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 589
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 629
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 789
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 873 AA; 98505 MW; BC89182D40485C64 CRC64;
MANSGTPANT LAVIQLLVTT FATIRDVTRL LRTEEIDNEL KAFYANVNAN CTLMTRDWSR
ISKSAYGIDE DLVSRTLSHL GSIITTSSLK PLQGSISSAT CYGGMRAFNQ EWNLIQKQSD
KSMRIQHVRS CTNFGKTLEE RNRFIQRLNE YEDELQARYP DFQPDWISED LLIKKSIRQP
SYAVWNAAQS IFKALVACSD CECTPSHEMW AQLGLGTYRK ASLNEEIDMD SGLDFDMFLS
IKQDWQEAHI LMSEEVKERA VVFQDDSEVK KPQTRKSIAK TKQMRVKRLC EPIAKMRTMA
AHRLELKVMR DQLFKLRSER STSLVDTTRS PITLEQFLKI GSRSFTERTR RILAVILSYA
VLYLHDTPWL QHTWSSSHIL FFPTTSSAIP LRPFIQIQLG QYQESRQDPD DLDDPDDLEL
ENLDPDDLIM HHCPFLVTLA VMLMEVYFAV PFNVLAKRYG YDIAPDAESS VSTRRCVDVE
LVFKACREEI PENYQFHCAV DKCLDPAAWE DESGNKLDNE ALTLRIYQEI VLPLETELGQ
AFTSMPIDEL DRIAQELNFP NWDQDDVYEK FIKPSSLNAV SSVKIAILDT GVDLSHPDFE
ARVDNIKGKY NWLSPNSNKP HVITDRNGHG TFAASLILDY APDAQLYIAK IAESEPSSAG
IIAKAINHAV STWEVDIISM SFGFPTCNTA DYHELEAALA HAHANRVLLF AAASNSGGKL
GHAYPARDQH VIAIHSTDTN GNRSAFSPTA MDHDINLATV GEAVESAWPV YLSDETSNPN
FVKYKSGTSY ATPIAAGIAG FLLLYSRIYL PDKASALKNR QKMQALLRQI AEKERGQTVR
DGYYFIDLSL YADCLFGKSL DFIDATIRNV LST
//
