ID G9NKF1_HYPAI Unreviewed; 2539 AA.
AC G9NKF1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=TRIATDRAFT_145665 {ECO:0000313|EMBL:EHK48374.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK48374.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK48374.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK48374.1}.
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DR EMBL; ABDG02000018; EHK48374.1; -; Genomic_DNA.
DR RefSeq; XP_013946545.1; XM_014091070.1.
DR STRING; 452589.G9NKF1; -.
DR GeneID; 25775805; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_000249_0_2_1; -.
DR OMA; TKEPYMF; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426}.
FT DOMAIN 1174..1367
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 1197..1224
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2539 AA; 282566 MW; 5B48D47953E884BB CRC64;
MSGDSSLVGC LVERLSSRLP HVTGTSSPNP LEDEVLHITR STLVDLSKAS IDTTLESLVA
LLEDLARPYH VVSEHPSLVL SSELFVLSLA ADCCSAHWAA QPNSRSSGTA LPSATLGERL
VVRTFDALKD LLEPISENYM LSAQALLDQS PEPGASVAFS ASGTPQDTLY DAADTKTSLT
SYLKEVEAHV KVLVGYVTAS SWSHSFSYLK SVIYSVRVAA AADIGPESGS NQESERGSLI
IVQLVSSFWV DSARLGSIIQ EFCSSYLHFR KSYQNAVAAA IPLLISRWID RYPQEFTHLH
RLHRRLDGGA DTLFDMTQTV TDARRKMLLF PLQTTLLFLM PDVFEVASNM REVRGGNIMK
KVSFLDGLRK AMKNGNEQAG YCVISLLRAA RHFNAESDSA LVSYAMDVQD EVRDAVFRHS
ATNSLSAQFD HNMITAAFIT LAHLNLDVCI DTVLDTCISP SSPYRFKVAV IQACCHLANL
PDSSKYNELF NDALPFIQSQ LKACVATQWD SAAILSNEVI NIARSILKFL GALPTPLINE
LTRQSPTIDT LGPFIFTVIS SNKTICQTAT EVAERLFAEH PDAIKAFNEH SHGEIVELRE
TFWTRSSKVI LELCERMVHP RLPELTTLHD YLKARLTILK NIPELTRLPD ELPDMVAASS
KLETVLLVSL CSADIDVCQL VTSCIGLFLA ECTCISEFTE SVKSSASVLR NGDIFREIAS
PAFRFTGLVA FQKRIRNLLR RIQFPTLGIL NAWEMAFDRW IFLVQKVSTL HPNSVDDRLL
SEWRNFSGFL ASLGGACTAG QANAAEDPSL QNLAWIDRSP AEQSEESSLK RYLKLAIQLL
ACANVRVREA MREILSSEVS PILYPALFKA LESELEVLFA GVLAPADTAQ ETDIIFAEQA
ASLLKTLVER LEIPADLTAA SSVHLGLITL NFAKFIDGIA DTANTLRVEI RVCQLCETVT
KRKEHLNLRD DVHIRNQVLE YIIGWIDRPR SPQVDQTGLV GRQDDLSRVQ KDLDKACLRA
LANLTFRLPL QPADSQSDVG MSEMKSQMFH TYFNRFLSLL NHESAEVSRS DLAATLPGRD
EAISNSDLAI TILSNLLSAN IDVGLKHSIN IGYHDNVEIR TAFVKVLFNI LVQGTEFSNL
TDSAVSKKYE EVLELITKDL SFSTSMSAIC PSTEVDELTI SLLTVFEQRG LIFDLFEALI
RAEIEQTENE AEILRRNCVA TKMLSVYARW KGFAYLQGTL HKVLERLMLT SQDLDLELDP
TRVGTQEELE KNALQLQIVA KVFMDDICAS ASNIPPSFRK ICSIISDAVL HRFPNAKYTA
VGAFIFLRFF CPAIVAPEVE GLVSTPPSKE MRRGLLLIAK IIQNLANNVL FGTKEPYMFP
LNLFLVQNIH VVIGFLREIS IPPSQMEVTV NKKAIDFGSC VALHRFLYDH WDHLRQILVS
RDSREFVRSP GEHAHGRSPA IEPLRNLISN LGPPPLAISW NRPQISTNSP PLYSRFQNFM
LRNAFRGTES YLTSRAVYDG GESKDGLSII CIILRHIEAD NIDYDTMLYC FLKIASRLWH
EPFGVFVDAT SYNGRNDPQD DFFKMLDLLT PSELALNMTR IYVYNMNSAF RRCFRHLLRV
STRTDNSAFH PRNVEYHLIG SLQDLQAHFH LSQLHLPKET ISVVTDTRYM FQPITRLSKS
KGKVEVVIKV GSQFVQVATT KKQEVLSGFR LSTTVNDIFR LGDVEEATTS LQSEDDSSFG
LRADGGKIVM YFTSPKKADV LQTIRSAKNK HGKENRTYKP FERLMRPQDV PGTLLNLAFT
NLLSSDRSLR LASYNLLGAL CRAFKFSADA RLSCAKDISV PIDPTKFVAE ISSILAATQP
QLTSDFLTEF FVGWESFPDE QKPLSLAYMS PWLAGLRTNV LTSEQDSEKG REKVATLLRK
LIDLIVLDQH LSYALQHFVL PSITTDELLL DIFLDELIKT ALSYGAHEDS LDIISPVIVG
IGTASIRGKI FSRLRKSLNR SSLRPTRYLQ DSPVWAEICV LLQFCVALSF DSGVQSRLFL
PEIFHIVTML ANTGDNSVRS LVYKLLVNSI HSVCTAFNLD EAKLTKLKAD LDLLCEPRGD
AFSLTSATMR DGASVSTAHD SNATLAATES LTVVLFDICS TAAPSVDLAN SWRSRWMSLV
ASTAFQINPA VQPRAFAVMG YLAREEVDDD LLYQVLVALR NSIGQFGEDG NSEMLVSIVT
SLSKMMIKLP SSSRYGLQLF WLAISLVRLV PIGLFNCTAQ FLEAVLTNIG AMNGATCEKI
VSLLLQSRAQ LEEAALPLDD AYGIHFDFEN FHFAVCACLV RGLTDTSTRP AAMRVLSSFF
EIVNSTPTPR APKDDPTTDS LPYLALISAR GVLHEDYRDG LWIAGINAEG VGDTTAFNSR
LKMESVRDED LLLISAIELV DFQYLEERVQ VRSLQWLNDI ALQRPLVFEQ LCGALPPLIE
DVLLHSQDSS ALKAANTLLR TISSKISFQD KMASTDILID KLHNMGFAGL SRFSSQDLRE
DIRQACFNLT ERLIELIII
//
