ID G9NMU1_HYPAI Unreviewed; 703 AA.
AC G9NMU1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN ORFNames=TRIATDRAFT_155050 {ECO:0000313|EMBL:EHK48221.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK48221.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK48221.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK48221.1}.
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DR EMBL; ABDG02000019; EHK48221.1; -; Genomic_DNA.
DR RefSeq; XP_013946385.1; XM_014090910.1.
DR AlphaFoldDB; G9NMU1; -.
DR MEROPS; M03.009; -.
DR GeneID; 25776296; -.
DR eggNOG; KOG2089; Eukaryota.
DR HOGENOM; CLU_001805_1_1_1; -.
DR OMA; RSGAWCS; -.
DR OrthoDB; 735202at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 224..699
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 703 AA; 80355 MW; 96EC1A745A17DC16 CRC64;
MAPEQFRNPP QSPPVFTATA DSILADAKKS AEKSKSILDQ IVATVTPETA TFDNTLKPIL
IDGNDSTGPQ NIQTFFQHVS TNESLREAST KAEELLNDFY IEAKMREDVF KLVDAAYSTR
DSQNLDKESL HILEKERQKY IRNGLLLPPG EKRDRFKEIK KRLSQLCILG KKNLNEEKGG
FWFTREELEG VPKDDIDVDT LEKGTGENEG KFKVTFKYNH YTPLMKYAIH EDTRRRYIIA
DANKSNNNVE IFKEIMELRD EAARLLGYPD HASVRIEEKM AKSPTRVNDF LGDLQVRLAP
GGKKEVEVLR GYKKRDYEER GIPFDGEFYM WDTSYYSRIM KEVEYSVDEV AISQYFPAES
TFAGMLKIFE EIFGFVFVEL GKEDRARLSP SGKADDISWH EDVIMYSVWD EAAKGGEFCG
YLYLDLFPRD NKYGHYANFG IEPGFTTVDG KRSYPSTSLV CNFSKPTATK PSLLKHHEVV
TFFHELGHGI HDLAGRSRFS YTHGTATVAD FVEAPSQMLE NWCWTPSVLK SLSKHWESGE
SIPDELVEKL VKTKHLNSAI GALGQLVIGT FDMTIHGPKT HEEAKTRNYG KLWNQIRHDI
SQIKGPEDIG ETMEWGNRYA NIGHFLGGYD AGYYGYLYSE VFSLDMFHSF FKKNPMDGKE
GRRYRHTVLE RGGSIDEMEF LKEFLGREPS TEAFYEELGI AAK
//
