ID G9P8S7_HYPAI Unreviewed; 3145 AA.
AC G9P8S7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:EHK41009.1};
GN ORFNames=TRIATDRAFT_30015 {ECO:0000313|EMBL:EHK41009.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK41009.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK41009.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK41009.1}.
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DR EMBL; ABDG02000027; EHK41009.1; -; Genomic_DNA.
DR RefSeq; XP_013938832.1; XM_014083357.1.
DR STRING; 452589.G9P8S7; -.
DR GeneID; 25781610; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_1_1; -.
DR OMA; LVCIDYM; -.
DR OrthoDB; 2301216at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1008..1084
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2514..2588
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2612..2686
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3145 AA; 349456 MW; E1C55F59AED6424D CRC64;
MDVRQQNQTA TPPLEFDVAG KQCDDLYEQV MVHCGLHRDK IETILPCTSS QIDVIDFAAT
DGKRAIGRAI YDIPRSVDTQ RLAIAWKEVV RQTPALRTYI FIPKVGCSFQ VVLAENFFSW
MYSTSIDMKE AIVHDETAAA MIGPRCNRYV VLEDIDKKQR LLIWTFSYAL VDSALQQHIL
QRVLTAYEGG KVQYSNWFGT SLSLQAGNLE RAARFWQQHF DGLDASIFPS LPSHLAAPHP
NTYAEHCISY LGPVQQKWSN TVVCRAALAV LLSGFTHSPE ALFGVVMKSS HKSEEEVDGL
AQAVVPIRVQ CSLEQSVLGI MEAITAHDHA MHEFAQVGLC NIRRMGDDES AACEFQTVLL
VTESDASQAP SCAILRNTEE SNKFIPCANR ALLLSCQMAS DSVLLAAHYD QSVIDAPQMT
RFLRQLGFLI QQLQQNMEHL PLVRHLDAVT QDDQAEIEAW NSERLQTQDA LIHDVISKRA
SDAPDSTAVS SWDGEWTYSE LDNVSSRLAA YIQSLDLGQG QAILPLCFEK SKWIIASILA
VLKAGRAFTL IDPCDPPARM AQVCRQTGAT VALTSSLHSS TITTIIDRCI VINDDFLQSL
SRDTDQLKPT AKPQDLAYCI FTSGSTGEPK GIMIEHRGFV SCAVKFGPAL GINPQTRALQ
FASYAFGACL VETVTVLMHG GCVCIPSDDD RMNSVPDFIR KSNINWVILT PSYIGTLQPE
NVSGLQTLVL VGEPISASIR DIWAPRVQLL HAYGQSESST ICSVTRVTPF TLEPNNIGRA
VGARSWIVDP NDSNKLVPIG CVGELVIESP GIARDYIVAL PPDESPFFVT TPVWYPTGQA
SGGFKFYRTG DLVRYRSDGT VVCLGRKDSQ VKIRGQRVEI SEVEARLRQQ LPGHIMPVAE
AVKTSDLSSG KTLIAFLIGS LQNEENGVFI APTSDTHVLD HSATKDINGT LQQVLPTYSV
PSYYISMKNL PRTATGKADR KKLRSIAGKL LSELAHNVRS QPCEKFGPPA TMTEVKLREL
WYRALNLDFN SENDGASFFE LGGDSIAAIR MVNMARIAGI PLKVSDIFQN PTFADLLDVI
GRDSTPYVSI PLTTYAKPVE QSFAQGRLWF LDQLELGASW YLLPYAVRMR GLLQTGALRV
ALLALEQRHE TLRTTFEEKD GVGVQVVHAS IFQELKTVDL SDDQNDGYLQ LLQQQQTTPF
DLASEAGWRV SLIRLGENDH VLSIVMHHII SDGWSTDILR RELGQFYAAA LQGHDPLSMV
KPLPIHYRDF SAWQKQEEQV AEHQKQLEYW TNQLANSSPA EFSTDFPRPT ILSGKAGYVP
VTIEGDLYRS LREFCRAKQM TPFTVLLAAF RAAHYRLTGT EDAVIGTPIA NRNRRELENI
IGFFVNTQCM RITVDDDETF ESLVRQVRLT ATAAFEHQDV PFDRVVSGLL PGSRDLSRNP
LAQLMFAVHS QQDFGNFELE GLEAEPLLNQ VYTRFDIEFH LFQETNRLSG NLVFAADLFE
LEKIRNVASV FFEILSQGLA KPHIPIAVIP FVDGVMELRN MGLLEVEKTG YPRDASIIDV
FRTQVDAYPH SFAVVDSKRR LTYSELDHQS NQIATWLRQR GIAPETLIGV FAPRSCETVI
AFFGILKANL AYLPLDINSP AARLRAILSS LPQHRLVLLG SDVTAPEIQL PGVDLAKISD
ILTECREVDD MNGDVDKTSP GPLATSLAYV IFTSGSTGRP KGVMVEHRSV VRLVKETRIT
SKFPLKFPFA VKMAHLSNIA FDAATWEIFA ALLNGGTLVC IDYMTILDSK EFEAVFAQEQ
VNAALFTPAL LKQCVANIPS ILKELEVLVI GGDRLDGQDS IAAQALVRAG VFNAYGPTEN
GVISTVYTIE KNDSFINGVP IGRPISNSGA YIMDSCQQIV PIGVVGELVV TGDGLARGYT
DPSLDAGRFV QVVIDGQAMR AYRTGDQGRY RPGDGQIEFL GRMDQQIKIR GHRIEPAEIE
RAFLSQDSVR DAVVVIRNHE SQEPEMVGFI VTQDDDHTAE QEEAGNQVEG WNDFFESNTY
ADIDTIAQSA IGNDFKGWTS MYDGNEIDKT EMHEWLDDTI HTLLDGQPPG HVLEIGTGSG
MILFNLGAGL QSYVGLEPSK SAATFVTKAI ESIPALDGRA NVHVGSATDV GQLDHLYPEL
VVLNSVVQYF PSSDYLEQLV DTLVRKPGVK RIFFGDIRSL ATNKHFLAAR ALHALGHKPT
RGAVRQKMTE MEEREEELLV DPAFFTMLEK RHPNHIKHIE ILPKKMQATN ELSAYRYAAI
IHIRGSEEQD KPLYQINMDE WIDFQESRVD QHTLLSLLKD STDALTVAVS NIPYRKTIFE
RHIVDSLDEE SGESETQNLL DGAAWISAVR ADAESCSSLS ATDLVRLGEE AGFRVEVSAA
RQWSQHGALD AVFHRYDLHT QKGHRALIRF PTDNKVRASA SLTNRPLQRL QSRRFVSQIR
EQLQSLLPSY MVPSHIVLID QMPLNANGKV DRKSLTRRAQ VMAQKPQERV QQVLPLNEIE
VVLCKEFAEV FGIQVGINDH FFKLGGHSLL ATKLTARIGR RLNTRVSVKD IFDQPVIGDL
AATIRRELAS RSSIPVSSYS GNGKQMMSAQ VAPRNEIETV LCEEFSYVLG IDVGITDHFF
DLGGHSLMAT KLASRISRRI GVTVSVKDIF DQPVPLHLAA KIELIQSENY EVTNGVQTNS
STSFQLISMG DPLAFIENEI SPQLGYSHGT IQDIYPATQM QRLFLFNPTT GHPRTPTPFY
IDFPSDSDCS SLETACKSLV GRIDIFRTIF LEVADELYQI VLKHLDLAIE IIETEENINS
ATRAFLDMDL KQPIRLGQPL IRITILRAQT SSLRVILRMS HALYDGLSLE HIVRSLHVLY
SGGILPPSAQ FSRYMQHIAD SRKEGYDFWR CLLQDSSMAV IRGVNRSAHQ EQVVSPGTYH
ASKVISVPLQ ANSSITPATV FTTACAIVLS KEAKTNDVVF GRIVSGRQGL PVTCQNIIGP
CTNEIPVRAY IHQDTDRKML LRKMQDQYLS SLSFEALGFD EIKKNCTDWP EAMTNYSCCI
AYQNFDYHPD SQMNEQRVQI GVLSRDIDAT KEVPLHDLVI SGEAELDGPY LHVTIAANRQ
VCEEGRVTHM LRELCETISS LNLAL
//
