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Database: UniProt
Entry: G9PE60_9ACTO
LinkDB: G9PE60_9ACTO
Original site: G9PE60_9ACTO 
ID   G9PE60_9ACTO            Unreviewed;      3141 AA.
AC   G9PE60;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN   ORFNames=HMPREF0045_00453 {ECO:0000313|EMBL:EHM89040.1};
OS   Actinomyces graevenitzii C83.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=435830 {ECO:0000313|EMBL:EHM89040.1, ECO:0000313|Proteomes:UP000003822};
RN   [1] {ECO:0000313|EMBL:EHM89040.1, ECO:0000313|Proteomes:UP000003822}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C83 {ECO:0000313|EMBL:EHM89040.1,
RC   ECO:0000313|Proteomes:UP000003822};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA   Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA   Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Actinomyces graevenitzii C83.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHM89040.1}.
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DR   EMBL; ACRN01000002; EHM89040.1; -; Genomic_DNA.
DR   RefSeq; WP_005985112.1; NZ_JH470338.1.
DR   STRING; 435830.HMPREF0045_00453; -.
DR   PATRIC; fig|435830.3.peg.440; -.
DR   eggNOG; COG0304; Bacteria.
DR   eggNOG; COG0331; Bacteria.
DR   eggNOG; COG2030; Bacteria.
DR   eggNOG; COG4981; Bacteria.
DR   HOGENOM; CLU_000114_7_0_11; -.
DR   OrthoDB; 4746285at2; -.
DR   Proteomes; UP000003822; Unassembled WGS sequence.
DR   GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR   GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00828; elong_cond_enzymes; 1.
DR   CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR   Gene3D; 1.20.930.70; -; 1.
DR   Gene3D; 3.30.70.3320; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.90.25.70; -; 1.
DR   Gene3D; 6.10.140.1400; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013565; Fas1/AflB-like_central.
DR   InterPro; IPR047224; FAS_alpha_su_C.
DR   InterPro; IPR003965; Fatty_acid_synthase.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR002539; MaoC-like_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF18094; DNA_pol_B_N; 1.
DR   Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF01575; MaoC_dehydratas; 1.
DR   PRINTS; PR01483; FASYNTHASE.
DR   SMART; SM00827; PKS_AT; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003822}.
FT   DOMAIN          2588..3053
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
SQ   SEQUENCE   3141 AA;  329532 MW;  8E8BD8D55CEA995F CRC64;
     MTTTSAKQSV ASRLHAGESF IVSFGGQATP WRETLESLVA TDSRLASELV AVDQAVRDRL
     APVATDLLTI SPAGGRMLDD EGGVVTSGSG AEVSVPGILL AQHAALVAAA HTSVDLIDSS
     LRPRAVIGHS QGMLGVALLE SLRAASAHRG ENNAEVVEIH AVARLIGAAA ARSVRRANLG
     PIGEVTPMLS VRGVPRAALD QVLNAAGLSE HISIGVTNGR AAFILSGRPA DLEAAVSALE
     FAAKRSEREH KERLRGGEVL APICEYLDTT VPFHSPLLEG AVEDTVEWAN RCGINPELAR
     YLAQAVLTDV VDWPATVREA VGTDATGKAE AKLIVDLGPG AVLARMSEAI VQGTGVTVVV
     AGTSAGIDKL DRSDYAPAPT VDRSAFAPHL SRLPDGRLSL DTAFTRLTGR SAIMLAGMTP
     TTVDPAIVAA AANAGYWAEL AGGGQVTAEV LNRNLAGLEA ALEPGRTAAF NAMFMDRYLW
     NLHLGTQRTL IRARAAGAPI DGIVITAGIP EREEAVPLLR RLRDEGFPYI ALKPGTVDQI
     KQVLAIAREV PEMPVIIEIE DGHAGGHHSW EDLDSMLLAT YDAIRAVDNV VLTVGGGIGK
     PERAADYITG RWALAYGTAP MPVDGVFVGS AAMTCLEAKT NDDVKQLLVD TPGISPSDNG
     GWVGSGKSAG GMTSGLSHLR ADLYEIDNSS AKASRLIQEL AGDEKLMAAR RDEMIEALSH
     TAKPYFGDME SMSYLQWAKR YAQLCVAPAS ARPEATKPAD YWADLDWADR LLDLLHRIEA
     RVSEADHGQI VTLFPDLDSV LDADAAIARL AEAYPAADTT LVEPADAAWF VDLCRKHPKP
     VPFVPVVDAD ILRWWGTDSL WQSQDPRYTA DQVRIIPGPV SVAGITTINE PVGHLLGRFE
     TAAVEALLAA GVDPVDAAAR LGECDGKAVG SRPVADVNAF VRSTPHVVWN GHLTTNPAVV
     LPSDAYQVVA RPDVAADAYD LDIKLDTHWD DLPGGEQIHA VRRLVVPLRL DGTSDGAAPE
     VDPSRISQTM GDLLVNTAGV GNVSIVGDHI TSLPAVQSAV AGALDANGKV ANQPFGTVHD
     TFTLASTLGY DHGAVTADAL PETLSAAAIV PDALLGPCWP VVYACLGSVV EDGMPLIEGL
     LGAVHLDHTV DLRADLEQLA AKQPSLRVSV DGWVEALEES SAGRVVAVHL ELRDFATGEL
     IAIMTERFAI RGRAHGTATP SAPAVAGGTG REIANSARRL LRRVKVTAPR DMTAFARVTG
     DFNPIHTSYN AAKVAGMSAP LVHGMWLSAT AQQVVASTDP EGGHYDIVGW TYTMHGPVEL
     GDQVEISVER TGLVRGGGFL LEATCRINGE IVSRGTAVTR AERTAYLYPG QGIQAQGMGL
     DERSSSKAAR EIWDRADAHT RKELGFSILA LVRDNPTELT ARGVTYRHPK GLLNLTQFTQ
     VALATVAMAT TARLEEAGAL VEGAAFAGHS LGEYTALSAY GRVFPVETMI SIVFQRGSTM
     HTLVPRAEDG SSNYRMGALR PNQCGIGASE VEAYVAEISQ RTGEFLQIVN YNLAGVQYAV
     AGTVAGLEAL AADARARAKA RGGKNPFMLV PGIDVPFHSS VLRPGVDEFR SRLDALVPAD
     IDIERMVGLY VPNLVARPFE LTQDFARSIL EVVPSAQVEA ILANWDAWIA QPVALGRALL
     IELLAWQFAS PVRWIETQDV LFTPVDRGGL GIEKVIEVGL AASPTLANLA SRTLALPHHA
     GNHVTVYNAR RDEARVLATD TDPAVADEVV VEEPAAPAAA EPAPAAAPAP AAAPVAAPAP
     AAPAGAPSGA DVADLPFTAK DGLNVLLAHS ARIRPDQIGA TDTTETLTNG VSSRRNQLLM
     DMGTELELAS IDGAADADMS ALAATVLKGA PNYKPFGPVL SEVIRQSISK LFGPSGQRPA
     RIAERVQRTW GLGEGWAAHV NAAVLLGTRE GASMRGDDLA TLGTTGPLKS AAEVDALIDR
     AVQAVASDHG VSVAMPSAGG SGGGAQVSSE ALDAFAAGLI GPDGALATTA RTLLDTLGLT
     EKVAVASEQV DDEAERTRVA LEAITAELGP NWVASVTPSF DSRRAVLIDD RWASAREDLA
     RIATGEINAE TVNAESYTGL GRAVADQAAW WARQMREAGA SERVAGVLEH ISQVAAIKAE
     AGSAPVRWAN EVAVVTGMAP HSIGAAVVAE LLSGGATVIA TASRLNHKRL EFATELYRQH
     ASNGAQLWMV PANLSSYRDV DALAQWIGNA EVVTSGGTST LVKPALVPTL LFPFAAGRVA
     GSLADAGPET ESQARLLLWS VERSIAALSA IGTDTNVDHR LHVILPGSPN RGTFGGDGAY
     GEVKSALDAI VNRWSSEKQW AQRVSLAHPR IGWVRGTGLM GGNDPLVAAV EAAGVRTWST
     EEIAHELVEL CTEQVRAQAA VKPVEADLTG GLGDNVDLVA LRENAAKAAA GQTSEPVEAS
     ATIAALPSPA TPVQPTAPNW GEVEADLEDM VVVVSTGEVS TWGSGRTRRE AELGMTGGDD
     VELTAAGVLE LAWGMGLLTW QDSPKAGWYD TEGNLVDEAD ILSRYRDEVV GRCGIREFVD
     DQLIAPVADE EVEVYLDRDI SFNVADEATA RTIADSDPAH TLISEDSESG EWIVTRLAGS
     LARVPRRAAL SRTVGGQFPR DFDPQRWGIP ASMTESLDRI ASWNLVTAVE AFLNAGFSPA
     ELLQAVHPAD VASTQGTGFG GMESMRKMFV GRFLNEERPS DILQEALPNV VAAHVMQSFI
     GGYGSMVQPV SACATAAVSI EEGWDKIALG KAQVVVAGAI DDISVESVVG FGNMNATAEA
     AAMKAKGISP RHFSRANDRR RGGFVEAQGG GTVILARGDV AAKLGLPVAA VLGFVSSYAD
     GAHTSIPAPG LGALAAGRGG SNSRLAKSLA KLGVEPDDIA VVSKHDTSTG ANDPNESELH
     TRLARALGRS EGNPLVAVSQ KTITGHAKGG AAVFQVAGLT EILATGVAPG NASLDCVDIK
     LKKDSFWIWP RKAMRLAGRG GESGRVPGAG PIRAGLATSL GFGHVSGLLA MVHPGAFESA
     LRKAGGQQAV DAWLASANAR LAAGTRRRRA GMIGRVALFE QIDGRRLGEE TETRDPHEVE
     AAMLLDPEAR LGADGVYHAG E
//
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