ID G9PE60_9ACTO Unreviewed; 3141 AA.
AC G9PE60;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=HMPREF0045_00453 {ECO:0000313|EMBL:EHM89040.1};
OS Actinomyces graevenitzii C83.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=435830 {ECO:0000313|EMBL:EHM89040.1, ECO:0000313|Proteomes:UP000003822};
RN [1] {ECO:0000313|EMBL:EHM89040.1, ECO:0000313|Proteomes:UP000003822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C83 {ECO:0000313|EMBL:EHM89040.1,
RC ECO:0000313|Proteomes:UP000003822};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces graevenitzii C83.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM89040.1}.
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DR EMBL; ACRN01000002; EHM89040.1; -; Genomic_DNA.
DR RefSeq; WP_005985112.1; NZ_JH470338.1.
DR STRING; 435830.HMPREF0045_00453; -.
DR PATRIC; fig|435830.3.peg.440; -.
DR eggNOG; COG0304; Bacteria.
DR eggNOG; COG0331; Bacteria.
DR eggNOG; COG2030; Bacteria.
DR eggNOG; COG4981; Bacteria.
DR HOGENOM; CLU_000114_7_0_11; -.
DR OrthoDB; 4746285at2; -.
DR Proteomes; UP000003822; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 6.10.140.1400; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000003822}.
FT DOMAIN 2588..3053
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 3141 AA; 329532 MW; 8E8BD8D55CEA995F CRC64;
MTTTSAKQSV ASRLHAGESF IVSFGGQATP WRETLESLVA TDSRLASELV AVDQAVRDRL
APVATDLLTI SPAGGRMLDD EGGVVTSGSG AEVSVPGILL AQHAALVAAA HTSVDLIDSS
LRPRAVIGHS QGMLGVALLE SLRAASAHRG ENNAEVVEIH AVARLIGAAA ARSVRRANLG
PIGEVTPMLS VRGVPRAALD QVLNAAGLSE HISIGVTNGR AAFILSGRPA DLEAAVSALE
FAAKRSEREH KERLRGGEVL APICEYLDTT VPFHSPLLEG AVEDTVEWAN RCGINPELAR
YLAQAVLTDV VDWPATVREA VGTDATGKAE AKLIVDLGPG AVLARMSEAI VQGTGVTVVV
AGTSAGIDKL DRSDYAPAPT VDRSAFAPHL SRLPDGRLSL DTAFTRLTGR SAIMLAGMTP
TTVDPAIVAA AANAGYWAEL AGGGQVTAEV LNRNLAGLEA ALEPGRTAAF NAMFMDRYLW
NLHLGTQRTL IRARAAGAPI DGIVITAGIP EREEAVPLLR RLRDEGFPYI ALKPGTVDQI
KQVLAIAREV PEMPVIIEIE DGHAGGHHSW EDLDSMLLAT YDAIRAVDNV VLTVGGGIGK
PERAADYITG RWALAYGTAP MPVDGVFVGS AAMTCLEAKT NDDVKQLLVD TPGISPSDNG
GWVGSGKSAG GMTSGLSHLR ADLYEIDNSS AKASRLIQEL AGDEKLMAAR RDEMIEALSH
TAKPYFGDME SMSYLQWAKR YAQLCVAPAS ARPEATKPAD YWADLDWADR LLDLLHRIEA
RVSEADHGQI VTLFPDLDSV LDADAAIARL AEAYPAADTT LVEPADAAWF VDLCRKHPKP
VPFVPVVDAD ILRWWGTDSL WQSQDPRYTA DQVRIIPGPV SVAGITTINE PVGHLLGRFE
TAAVEALLAA GVDPVDAAAR LGECDGKAVG SRPVADVNAF VRSTPHVVWN GHLTTNPAVV
LPSDAYQVVA RPDVAADAYD LDIKLDTHWD DLPGGEQIHA VRRLVVPLRL DGTSDGAAPE
VDPSRISQTM GDLLVNTAGV GNVSIVGDHI TSLPAVQSAV AGALDANGKV ANQPFGTVHD
TFTLASTLGY DHGAVTADAL PETLSAAAIV PDALLGPCWP VVYACLGSVV EDGMPLIEGL
LGAVHLDHTV DLRADLEQLA AKQPSLRVSV DGWVEALEES SAGRVVAVHL ELRDFATGEL
IAIMTERFAI RGRAHGTATP SAPAVAGGTG REIANSARRL LRRVKVTAPR DMTAFARVTG
DFNPIHTSYN AAKVAGMSAP LVHGMWLSAT AQQVVASTDP EGGHYDIVGW TYTMHGPVEL
GDQVEISVER TGLVRGGGFL LEATCRINGE IVSRGTAVTR AERTAYLYPG QGIQAQGMGL
DERSSSKAAR EIWDRADAHT RKELGFSILA LVRDNPTELT ARGVTYRHPK GLLNLTQFTQ
VALATVAMAT TARLEEAGAL VEGAAFAGHS LGEYTALSAY GRVFPVETMI SIVFQRGSTM
HTLVPRAEDG SSNYRMGALR PNQCGIGASE VEAYVAEISQ RTGEFLQIVN YNLAGVQYAV
AGTVAGLEAL AADARARAKA RGGKNPFMLV PGIDVPFHSS VLRPGVDEFR SRLDALVPAD
IDIERMVGLY VPNLVARPFE LTQDFARSIL EVVPSAQVEA ILANWDAWIA QPVALGRALL
IELLAWQFAS PVRWIETQDV LFTPVDRGGL GIEKVIEVGL AASPTLANLA SRTLALPHHA
GNHVTVYNAR RDEARVLATD TDPAVADEVV VEEPAAPAAA EPAPAAAPAP AAAPVAAPAP
AAPAGAPSGA DVADLPFTAK DGLNVLLAHS ARIRPDQIGA TDTTETLTNG VSSRRNQLLM
DMGTELELAS IDGAADADMS ALAATVLKGA PNYKPFGPVL SEVIRQSISK LFGPSGQRPA
RIAERVQRTW GLGEGWAAHV NAAVLLGTRE GASMRGDDLA TLGTTGPLKS AAEVDALIDR
AVQAVASDHG VSVAMPSAGG SGGGAQVSSE ALDAFAAGLI GPDGALATTA RTLLDTLGLT
EKVAVASEQV DDEAERTRVA LEAITAELGP NWVASVTPSF DSRRAVLIDD RWASAREDLA
RIATGEINAE TVNAESYTGL GRAVADQAAW WARQMREAGA SERVAGVLEH ISQVAAIKAE
AGSAPVRWAN EVAVVTGMAP HSIGAAVVAE LLSGGATVIA TASRLNHKRL EFATELYRQH
ASNGAQLWMV PANLSSYRDV DALAQWIGNA EVVTSGGTST LVKPALVPTL LFPFAAGRVA
GSLADAGPET ESQARLLLWS VERSIAALSA IGTDTNVDHR LHVILPGSPN RGTFGGDGAY
GEVKSALDAI VNRWSSEKQW AQRVSLAHPR IGWVRGTGLM GGNDPLVAAV EAAGVRTWST
EEIAHELVEL CTEQVRAQAA VKPVEADLTG GLGDNVDLVA LRENAAKAAA GQTSEPVEAS
ATIAALPSPA TPVQPTAPNW GEVEADLEDM VVVVSTGEVS TWGSGRTRRE AELGMTGGDD
VELTAAGVLE LAWGMGLLTW QDSPKAGWYD TEGNLVDEAD ILSRYRDEVV GRCGIREFVD
DQLIAPVADE EVEVYLDRDI SFNVADEATA RTIADSDPAH TLISEDSESG EWIVTRLAGS
LARVPRRAAL SRTVGGQFPR DFDPQRWGIP ASMTESLDRI ASWNLVTAVE AFLNAGFSPA
ELLQAVHPAD VASTQGTGFG GMESMRKMFV GRFLNEERPS DILQEALPNV VAAHVMQSFI
GGYGSMVQPV SACATAAVSI EEGWDKIALG KAQVVVAGAI DDISVESVVG FGNMNATAEA
AAMKAKGISP RHFSRANDRR RGGFVEAQGG GTVILARGDV AAKLGLPVAA VLGFVSSYAD
GAHTSIPAPG LGALAAGRGG SNSRLAKSLA KLGVEPDDIA VVSKHDTSTG ANDPNESELH
TRLARALGRS EGNPLVAVSQ KTITGHAKGG AAVFQVAGLT EILATGVAPG NASLDCVDIK
LKKDSFWIWP RKAMRLAGRG GESGRVPGAG PIRAGLATSL GFGHVSGLLA MVHPGAFESA
LRKAGGQQAV DAWLASANAR LAAGTRRRRA GMIGRVALFE QIDGRRLGEE TETRDPHEVE
AAMLLDPEAR LGADGVYHAG E
//