ID G9PEL0_9ACTO Unreviewed; 284 AA.
AC G9PEL0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=HMPREF0045_00684 {ECO:0000313|EMBL:EHM88886.1};
OS Actinomyces graevenitzii C83.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=435830 {ECO:0000313|EMBL:EHM88886.1, ECO:0000313|Proteomes:UP000003822};
RN [1] {ECO:0000313|EMBL:EHM88886.1, ECO:0000313|Proteomes:UP000003822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C83 {ECO:0000313|EMBL:EHM88886.1,
RC ECO:0000313|Proteomes:UP000003822};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces graevenitzii C83.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM88886.1}.
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DR EMBL; ACRN01000003; EHM88886.1; -; Genomic_DNA.
DR AlphaFoldDB; G9PEL0; -.
DR STRING; 435830.HMPREF0045_00684; -.
DR PATRIC; fig|435830.3.peg.656; -.
DR HOGENOM; CLU_021594_1_0_11; -.
DR Proteomes; UP000003822; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000003822}.
FT DOMAIN 1..160
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 227..279
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 284 AA; 30368 MW; 274AFF271FD4593B CRC64;
MVGRTHLQDA TPITLGQVIS GWVAQIDFAL DGIRYADSRA RELAIGGTAV GTGLNAHPDF
GALTAKKISE ETGIEFKQAD NLFAALSAHD ALVLVSGSLR VLGDALMKIA NDVRWYASGP
RNGIGELIIP ENEPGSSIMP GKVNPTQCEA MTMVAVQVFG NDAAVGFAGS QGNFQLNVFK
PVMAWNVLES IRLLGDACVS FDVHCAYGIE PNYAKIKHNL DINLMQVTAL NRHIGYDKAS
KIAKNAHHKG ISLRESALEL GFLTDAEFDA WVVPADMTHP SAAK
//