ID G9PMW8_9ACTO Unreviewed; 770 AA.
AC G9PMW8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN ORFNames=HMPREF0975_01739 {ECO:0000313|EMBL:EHM94117.1};
OS Actinomyces sp. oral taxon 849 str. F0330.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=653386 {ECO:0000313|EMBL:EHM94117.1, ECO:0000313|Proteomes:UP000003600};
RN [1] {ECO:0000313|EMBL:EHM94117.1, ECO:0000313|Proteomes:UP000003600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0330 {ECO:0000313|EMBL:EHM94117.1,
RC ECO:0000313|Proteomes:UP000003600};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C.,
RA Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces sp. oral taxon 849 str. F0330.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM94117.1}.
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DR EMBL; ACTB01000095; EHM94117.1; -; Genomic_DNA.
DR AlphaFoldDB; G9PMW8; -.
DR STRING; 653386.HMPREF0975_01739; -.
DR PATRIC; fig|653386.3.peg.1618; -.
DR eggNOG; COG4409; Bacteria.
DR HOGENOM; CLU_368301_0_0_11; -.
DR Proteomes; UP000003600; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR023364; Trans_sialidase_dom3.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13088; BNR_2; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000003600};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 506..732
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
SQ SEQUENCE 770 AA; 84666 MW; 8856CB2743245FB9 CRC64;
MGSVCAEMRL DEEILEAERG SISFEFRSRS DGNLFLLRGA DAHSLEMRIV GSSLVYEAAV
PGKWNKLEAE DIRSLDDGRW HSAVVTVDSA GTRLYVDGYQ AFCGTTTAFL KDLPGLTQAI
LGQGDSPEIT AFRVRPEVLT SREVLALSRR VQPLVEFAAN RLSPYDVTRF CHARHGSVWL
RFRVRGRMQQ GALLAASGLG REQLSVTVGP EGITYTCVSA TGERREVQAN GAWSDGDWHE
VVVTVGHGAV DLYVDGFREK HAPGEFFLGE VEGLDEILVG QDCDGVRLSG EVQRAGLYDY
ALSDAQIKRL CEIEPIETDA LFDRGYRGSA SYRIPSLLTL TSGTILAGAD QRVSSANDSP
NDINFVVRRS LDGGRSWEPA RTVIDCPGSG EDASSVIDSC MVQDPHTGRI HVLIDHFPGG
IGQPNCWAST GFDEQGRRLL RDLDDGRYVV EADGKVTTID GQATEFRIED DGTVLRDGHP
AGNFELAPGA DPAESLLAIP TSYLQIAHSD DDGATWSKPR DLNPQLKQPW MRFLGTCPGN
GIALRHGPRP GRLVIPLYFN NDGNWLAMCA TVAYSDDHGE TWNLGHGPND GRRTPDGALD
PRTFVDETWS LHEAAVVERR DGTLVLYMRN QHPCGRVAVS ESHDAGQTWG PIDFDEDLPE
IWCQPNAICL PSAEGEDRIV FANASLMLPF RGCGVIRLSL DGGRTWRRSR TFNPGHYVYQ
CMCALPDGRI GILWENECQG LYFSRIPLSW FDADVESIEP HTTADQDGRL
//
