ID   G9VYV6_STRAT            Unreviewed;       487 AA.
AC   G9VYV6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Putative halogenase {ECO:0000313|EMBL:AEU17894.1};
GN   Name=simC6 {ECO:0000313|EMBL:AEU17894.1};
OS   Streptomyces antibioticus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1890 {ECO:0000313|EMBL:AEU17894.1};
RN   [1] {ECO:0000313|EMBL:AEU17894.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tue6040 {ECO:0000313|EMBL:AEU17894.1};
RX   PubMed=11959542; DOI=10.1128/AAC.46.5.1174-1182.2002;
RA   Trefzer A., Pelzer S., Schimana J., Stockert S., Bihlmaier C.,
RA   Fiedler H.P., Welzel K., Vente A., Bechthold A.;
RT   "Biosynthetic gene cluster of simocyclinone, a natural multihybrid
RT   antibiotic.";
RL   Antimicrob. Agents Chemother. 46:1174-1182(2002).
RN   [2] {ECO:0000313|EMBL:AEU17894.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tue6040 {ECO:0000313|EMBL:AEU17894.1};
RA   Trefzer A., Bechthold A.;
RT   "The simocyclinone biosynthetic gene cluster isolated from Streptomyces
RT   antibioticus Tue6040.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC       Bacterial tryptophan halogenase subfamily.
CC       {ECO:0000256|ARBA:ARBA00038396}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF324838; AEU17894.1; -; Genomic_DNA.
DR   AlphaFoldDB; G9VYV6; -.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   Gene3D; 3.30.9.100; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   Pfam; PF04820; Trp_halogenase; 2.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ   SEQUENCE   487 AA;  52752 MW;  0744DDDD210513DD CRC64;
     MTQVIVVGGG PAGSTAAALL ARAGISVTVL ERATFPRYHI GESFSTSCRV IIDYLGALEK
     VDARGYTSKT GLLVRWGQEK DWAIDWTDQF GSDVRSWQVD RDDFDTVLLD HASESGAKVV
     QGAHVHRVIF EGDRATGVEW TAPGETAKQI SRADFVLDAS GRAGLISAQH FNNRRPHEIF
     RNVAIWGYWE GGELLPGSPS GGINVISSDD GWYWVIPLRD NRLSVGFVSH KSIFGERRRE
     FGSLDEMLLK MVDESPAVRE ILAKGTFQPG ARVEQDFSYS ADSFCGPGHF LLGDAACFLD
     PLLSTGVHLG MYSGLLAAAS VMAITDGDVS EREALAFYES LFRNAYQRLF TLVSGFYQKH
     AGKDRYFALA ETLARQEPEH WHSSAQSFGE ITAGLTDMRE AADAGGRGGR PIQEIIERAA
     TGEPTPVQQL LIAAALAESR AQGDTAPGAR LTNAPGVIDA NDLYDAGTGL HLVMQPRLGI
     GSVTSQK
//