ID   G9Y6E4_HAFAL            Unreviewed;       518 AA.
AC   G9Y6E4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase PaaC {ECO:0000313|EMBL:EHM42775.1};
GN   ORFNames=HMPREF0454_02176 {ECO:0000313|EMBL:EHM42775.1};
OS   Hafnia alvei ATCC 51873.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Hafnia.
OX   NCBI_TaxID=1002364 {ECO:0000313|EMBL:EHM42775.1, ECO:0000313|Proteomes:UP000005959};
RN   [1] {ECO:0000313|EMBL:EHM42775.1, ECO:0000313|Proteomes:UP000005959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51873 {ECO:0000313|EMBL:EHM42775.1,
RC   ECO:0000313|Proteomes:UP000005959};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHM42775.1}.
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DR   EMBL; AGCI01000048; EHM42775.1; -; Genomic_DNA.
DR   RefSeq; WP_004847164.1; NZ_JH417518.1.
DR   AlphaFoldDB; G9Y6E4; -.
DR   PATRIC; fig|1002364.3.peg.1972; -.
DR   HOGENOM; CLU_009834_2_2_6; -.
DR   Proteomes; UP000005959; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.30.750.190; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR041040; 3HCDH_RFF.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF18321; 3HCDH_RFF; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          9..186
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          190..287
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          354..421
FT                   /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT                   fold"
FT                   /evidence="ECO:0000259|Pfam:PF18321"
FT   DOMAIN          427..502
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   518 AA;  55955 MW;  AE3F6D2DFEFCD035 CRC64;
     MSSFLLQGSV AVIGAGTMGI GIAQVAAAAG HNVLLFDVNV EASTRALAAL QQRLRQRVEA
     GKADANDTEQ LLERIQVVTA LTELAACALA IEAIAERLDV KQSLFRDLEA ICSQQTLFAS
     NTSSLSITAI ASALKHPQRM AGLHFFNPAP VMKLVEIVRG LETAQSTLNL LQQLAVAWKK
     QPVICRSAPG FIVNRVARPF YAETLRALEE QVASPATLDA ALRDAGGFTM GPLQLTDLIG
     HDVNYAVTES VFRAFGYDPR FHPSLVQQEL VNAGHLGRKS GRGFYRYDSA ATQEQPAFSG
     IENGPLPQRI TAHGRWSSLP HFAALLQQNG IAIEEQKESA ESAPFLRLDE VTFMLSKGKL
     SSEVAEEMRT PVVQFDLSAN YQQASAITIS AASCNTAAQT ALVIRFLQSL GKNVIVLPDY
     PALLTLRTVA MLCNEALDAL NKGIASAADL DLAMCRGVNY PLGPLAWGQQ LGWQHILATL
     ENLNVFYAEP RYRPTSLLRQ LAAGYVSLSF SATQDLIP
//