ID G9Y8N5_HAFAL Unreviewed; 1105 AA.
AC G9Y8N5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Transporter, small conductance mechanosensitive ion channel MscS family protein {ECO:0000313|EMBL:EHM41398.1};
GN ORFNames=HMPREF0454_02946 {ECO:0000313|EMBL:EHM41398.1};
OS Hafnia alvei ATCC 51873.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Hafnia.
OX NCBI_TaxID=1002364 {ECO:0000313|EMBL:EHM41398.1, ECO:0000313|Proteomes:UP000005959};
RN [1] {ECO:0000313|EMBL:EHM41398.1, ECO:0000313|Proteomes:UP000005959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51873 {ECO:0000313|EMBL:EHM41398.1,
RC ECO:0000313|Proteomes:UP000005959};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM41398.1}.
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DR EMBL; AGCI01000068; EHM41398.1; -; Genomic_DNA.
DR RefSeq; WP_004093593.1; NZ_JH417532.1.
DR AlphaFoldDB; G9Y8N5; -.
DR PATRIC; fig|1002364.3.peg.2657; -.
DR HOGENOM; CLU_007829_2_0_6; -.
DR Proteomes; UP000005959; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1105
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003529136"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..260
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 482..817
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 878..919
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 921..986
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 994..1076
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 746..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..289
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 746..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 123885 MW; 5B760C44251E694D CRC64;
MRLITKLLIT GLLMLSLPLG ANAALNEKQL AQELKQAESN KNAPNQAEIV ETLQSALNWL
NESKESAQRT QQYQKSISDF PKLTRELRQQ LSDESTPPLP ASAIPANEAE QQILQISSQL
LEVSRQLQQE LDRSREISDS LGQVPQKQAT ARKDLTEAER RLQNLTTTST PLSQAQSNQL
QAEVAARKAL VDELELEQLS ANNRQELARL QADVLRKRHE RLDLQLQDLR NTLNSQRQRE
AEQALERTQQ LVEQSGDLPR SIAEQLKINQ ELSRALNQQA ARMDDIASQQ RIAATQTIQV
RQALSTIREQ AQWLGVSTAL GETLRAQVAR LPDMPKPQQL DGDMAKLRVQ RLHFENLLNK
IEPVADYKQN DGKPLTAAQQ RLLQPQLTTQ RELLNSLLSG CDSQILELTK LKVANTQLID
ALTEIKDATH RYLFWAADVD PLSVAAPLDV IQSLNRLLSL DTLSQLSKAF LMMLTSKETL
LPLFGALLLV GFSFYSRRHY QAFMERASSK VGKVTQDHIS LTLRTVFWSI LVALPLPVLW
AALGYGLQNA WPYPMAVAIG DGVTAALPVL WAFMISAAFA HPNGLFIAHF RWEEQQVKRA
MRYYRMSIWL IVPLLMALVT FDNMDDRAFA GSLGRACFIM LCVALSLLTT SLKRAGIPLY
LNKQGDGENL INHALWWILL CAPLVAAFAS LFGYFNTAQI LLARLESSVA IWFILLVVYY
IIRRWMLIQR RRIAFERAKQ RRAERLEKRT KGEEESTPHS VEGSQDIEEP VVDLDAISAQ
SLRLVRSILT MVALVSLIWL WSELHSAFAF LENISLWDVT SSAKGVESIQ PITLGAVLIA
ILVMIVTVQL VKNLPALLEL GLLQHLDLTP GTGYAITTIT KYLLLLFGGL IGFSMLGIEW
AKLQWLVAAL TLGLGFGLQE IVANFASGLI ILFEKPIRIG DTVTIRDLTG SVTKINTRAT
TISDWDRKEI IVPNKAFITE QFINWSLSDA VTRVVLTVPA EASANSQEVT DVLLEAASKC
SLVLDTPAPE AYLVDIQQGI QIFELRIYAA EMAHRMPLRH EIHQLILAGF QQHDLKLPFP
PFQVSTDTLR QSRNSMRRTF TTGSL
//
