ID G9ZF28_9GAMM Unreviewed; 656 AA.
AC G9ZF28;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Ketol-acid reductoisomerase (NADP(+)) {ECO:0000256|ARBA:ARBA00015731};
DE EC=1.1.1.86 {ECO:0000256|ARBA:ARBA00013102};
GN ORFNames=HMPREF9080_01370 {ECO:0000313|EMBL:EHM54227.1};
OS Cardiobacterium valvarum F0432.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cardiobacteriales;
OC Cardiobacteriaceae; Cardiobacterium.
OX NCBI_TaxID=797473 {ECO:0000313|EMBL:EHM54227.1, ECO:0000313|Proteomes:UP000004750};
RN [1] {ECO:0000313|EMBL:EHM54227.1, ECO:0000313|Proteomes:UP000004750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0432 {ECO:0000313|EMBL:EHM54227.1,
RC ECO:0000313|Proteomes:UP000004750};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-
CC acetolactate + H(+) + NADPH; Xref=Rhea:RHEA:22068, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:49072, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:58476; EC=1.1.1.86;
CC Evidence={ECO:0000256|ARBA:ARBA00000507};
CC -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
CC {ECO:0000256|PROSITE-ProRule:PRU01198}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01198}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM54227.1}.
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DR EMBL; AGCM01000074; EHM54227.1; -; Genomic_DNA.
DR AlphaFoldDB; G9ZF28; -.
DR STRING; 797473.HMPREF9080_01370; -.
DR PATRIC; fig|797473.3.peg.1104; -.
DR HOGENOM; CLU_417812_0_0_6; -.
DR Proteomes; UP000004750; Unassembled WGS sequence.
DR GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.550.60; -; 1.
DR Gene3D; 6.10.240.10; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR000506; KARI_C.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR Pfam; PF01450; IlvC; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51851; KARI_C; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|PROSITE-ProRule:PRU01198};
KW Branched-chain amino acid biosynthesis {ECO:0000256|PROSITE-
KW ProRule:PRU01198};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|PROSITE-
KW ProRule:PRU01198}; Transferase {ECO:0000313|EMBL:EHM54227.1}.
FT DOMAIN 600..645
FT /note="KARI C-terminal knotted"
FT /evidence="ECO:0000259|PROSITE:PS51851"
SQ SEQUENCE 656 AA; 75803 MW; 1260E19841FAFC4A CRC64;
MYIVQHLQFA FPTIPEKLFY TGSDGEHACQ VKEDGLHLAA YGRQVSLNLT TLFNSFPAEH
FLINTRAQQV YLQLRFSGRA DSITVYRKTR WHSEKIHTEP APAEGDILLG PFPLEKNTKR
YAFSIETRAD IILHAGCWLV DAEPQDKSVD ICITTFKKEH YVTANVSALL AYPPLAAMNY
RITVVDNGST LGTDDFPHAD NFILIRQANL GGTGGFMRGL LDARDKQSDY ILFMDDDILL
VPEMIYRAVA IAQIAKPKRA FGGMMLHYTR KDKIHEQGGR LPWKIHNFFQ AINDDAILKK
TQQKVAQEAL AASGQAEKVA ADSDLYAPLY SEGHPDFSGW WFYMAETRDT PILPNYFFKW
DDICSSLYLR QRGTAISVFP TIFVWHEDFS IKRHLMMTDY LSMRNEVLTF AFLNIPAKQM
KIAFRRTFAM IVRDILMYDY RRAEIRLKAL HDALDYRRIL SPQFVADGHG DYPVKLAREY
MPELTDIDNN IDIFYEQEKA RYPRGTFVKR ALRMMLASIR LIIPWKKAAL DNGKIPLLSM
DNGNFPIIYP YRQYFLYNPD GSTGYYCTYS GRKTRELLWQ TWKTVRQVRA AYPQIAAYMQ
NGEYAKRFIT EYKVGAPSMT ARRRQNAEHP IEIVGAKLRD MMPWIKANRL VDQEKN
//
