ID GLOD5_HUMAN Reviewed; 160 AA.
AC A6NK44;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 3.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Glyoxalase domain-containing protein 5;
GN Name=GLOD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 34-157.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the human glyoxalase domain-containing protein 5.";
RL Submitted (AUG-2011) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the glyoxalase I family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-13 is the initiator.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC115617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF196970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55410.1; -.
DR RefSeq; NP_001073958.2; NM_001080489.2.
DR PDB; 3ZW5; X-ray; 1.60 A; A/B=34-157.
DR PDBsum; 3ZW5; -.
DR AlphaFoldDB; A6NK44; -.
DR SMR; A6NK44; -.
DR BioGRID; 134231; 1.
DR IntAct; A6NK44; 1.
DR STRING; 9606.ENSP00000302552; -.
DR GlyGen; A6NK44; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A6NK44; -.
DR PhosphoSitePlus; A6NK44; -.
DR BioMuta; GLOD5; -.
DR MassIVE; A6NK44; -.
DR PaxDb; 9606-ENSP00000302552; -.
DR PeptideAtlas; A6NK44; -.
DR ProteomicsDB; 1376; -.
DR Antibodypedia; 546; 24 antibodies from 8 providers.
DR DNASU; 392465; -.
DR Ensembl; ENST00000303227.11; ENSP00000302552.6; ENSG00000171433.12.
DR GeneID; 392465; -.
DR KEGG; hsa:392465; -.
DR MANE-Select; ENST00000303227.11; ENSP00000302552.6; NM_001080489.3; NP_001073958.2.
DR UCSC; uc011mmh.3; human.
DR AGR; HGNC:33358; -.
DR CTD; 392465; -.
DR GeneCards; GLOD5; -.
DR HGNC; HGNC:33358; GLOD5.
DR HPA; ENSG00000171433; Group enriched (epididymis, intestine, kidney, liver).
DR MIM; 301112; gene.
DR neXtProt; NX_A6NK44; -.
DR OpenTargets; ENSG00000171433; -.
DR VEuPathDB; HostDB:ENSG00000171433; -.
DR eggNOG; ENOG502RZMP; Eukaryota.
DR GeneTree; ENSGT00940000153941; -.
DR InParanoid; A6NK44; -.
DR OMA; FGTHKIN; -.
DR OrthoDB; 11637at2759; -.
DR PhylomeDB; A6NK44; -.
DR TreeFam; TF300075; -.
DR PathwayCommons; A6NK44; -.
DR SignaLink; A6NK44; -.
DR BioGRID-ORCS; 392465; 11 hits in 716 CRISPR screens.
DR EvolutionaryTrace; A6NK44; -.
DR GenomeRNAi; 392465; -.
DR Pharos; A6NK44; Tdark.
DR PRO; PR:A6NK44; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A6NK44; Protein.
DR Bgee; ENSG00000171433; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 76 other cell types or tissues.
DR ExpressionAtlas; A6NK44; baseline and differential.
DR Genevisible; A6NK44; HS.
DR CDD; cd07253; GLOD5; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR21366:SF22; GLYOXALASE DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR21366; GLYOXALASE FAMILY PROTEIN; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS51819; VOC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..160
FT /note="Glyoxalase domain-containing protein 5"
FT /id="PRO_0000305326"
FT DOMAIN 37..157
FT /note="VOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT STRAND 36..46
FT /evidence="ECO:0007829|PDB:3ZW5"
FT HELIX 48..59
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 62..66
FT /evidence="ECO:0007829|PDB:3ZW5"
FT TURN 67..69
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 78..84
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 102..106
FT /evidence="ECO:0007829|PDB:3ZW5"
FT HELIX 111..120
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 127..134
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 137..145
FT /evidence="ECO:0007829|PDB:3ZW5"
FT STRAND 151..156
FT /evidence="ECO:0007829|PDB:3ZW5"
SQ SEQUENCE 160 AA; 18322 MW; CB59F7A2814C0E96 CRC64;
MLRHLPSRLP VKMWGRTLEK QSWRDSSQTP PPCLIRRLDH IVMTVKSIKD TTMFYSKILG
MEVMTFKEDR KALCFGDQKF NLHEVGKEFE PKAAHPVPGS LDICLITEVP LEEMIQHLKA
CDVPIEEGPV PRTGAKGPIM SIYFRDPDRN LIEVSNYISS
//
