ID GMPAA_DANRE Reviewed; 422 AA.
AC Q6GMK8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Mannose-1-phosphate guanyltransferase alpha-A;
DE EC=2.7.7.13;
DE AltName: Full=GDP-mannose pyrophosphorylase A-A;
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A;
GN Name=gmppaa; ORFNames=zgc:91853;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000305}.
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DR EMBL; BC074036; AAH74036.1; -; mRNA.
DR RefSeq; NP_001002196.1; NM_001002196.1.
DR AlphaFoldDB; Q6GMK8; -.
DR SMR; Q6GMK8; -.
DR STRING; 7955.ENSDARP00000017348; -.
DR PaxDb; 7955-ENSDARP00000017348; -.
DR GeneID; 431743; -.
DR KEGG; dre:431743; -.
DR AGR; ZFIN:ZDB-GENE-040704-37; -.
DR CTD; 431743; -.
DR ZFIN; ZDB-GENE-040704-37; gmppaa.
DR eggNOG; KOG1460; Eukaryota.
DR HOGENOM; CLU_029499_3_0_1; -.
DR InParanoid; Q6GMK8; -.
DR OrthoDB; 5486038at2759; -.
DR PhylomeDB; Q6GMK8; -.
DR TreeFam; TF300832; -.
DR UniPathway; UPA00126; UER00930.
DR PRO; PR:Q6GMK8; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000024112; Expressed in testis and 27 other cell types or tissues.
DR ExpressionAtlas; Q6GMK8; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1..422
FT /note="Mannose-1-phosphate guanyltransferase alpha-A"
FT /id="PRO_0000327876"
SQ SEQUENCE 422 AA; 47011 MW; 7A7986D2599C7E4C CRC64;
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACSKLPNM KEILLIGFYQ
PNEELNRFLS CAQQDFKISI RYLQEYAALG TGGGIYHFRD QILSGGPDAF FVMNADVCSE
FPLPEMLDFQ KEHGDTYSFV ILGTTANRKQ SLNYGCIVEN EQTDEVLHYV EKPGTFVSDI
INCGIYLFTP EIFQHIGSVF QKNQQEMLLE EQSNGWHRAE VIRLEQDIFT ALAGQGKLYV
YKTDRFWSQI KSAGSAIYAS RLYLNQYHKT HPERLATNTE GGAKTRGNVY IHPTANIDPT
AVLGPNVSIG TGVTIGAGVR VRESIILHGA TLQDHSCVLN SIVGWESTIG KWARVEGTPS
DPNPNDPYAK IDSETLFRDG KLTPSITILG CNVNIPSEVI ILNSIVLPHK DLNRSFKNQI
IL
//
