ID GNTK_XENTR Reviewed; 190 AA.
AC B0BML1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Probable gluconokinase;
DE EC=2.7.1.12;
DE AltName: Full=Gluconate kinase;
GN Name=idnk;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC EC=2.7.1.12;
CC -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation.
CC -!- SIMILARITY: Belongs to the gluconokinase GntK/GntV family.
CC {ECO:0000305}.
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DR EMBL; BC158476; AAI58477.1; -; mRNA.
DR RefSeq; NP_001120064.1; NM_001126592.1.
DR AlphaFoldDB; B0BML1; -.
DR SMR; B0BML1; -.
DR STRING; 8364.ENSXETP00000046879; -.
DR PaxDb; 8364-ENSXETP00000057500; -.
DR GeneID; 100145063; -.
DR KEGG; xtr:100145063; -.
DR AGR; Xenbase:XB-GENE-972317; -.
DR CTD; 414328; -.
DR eggNOG; KOG3354; Eukaryota.
DR HOGENOM; CLU_077168_4_1_1; -.
DR InParanoid; B0BML1; -.
DR OMA; MACSALK; -.
DR OrthoDB; 5473338at2759; -.
DR UniPathway; UPA00792; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046316; F:gluconokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02021; GntK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR006001; Therm_gnt_kin.
DR NCBIfam; TIGR01313; therm_gnt_kin; 1.
DR PANTHER; PTHR43442; GLUCONOKINASE-RELATED; 1.
DR PANTHER; PTHR43442:SF3; GLUCONOKINASE-RELATED; 1.
DR Pfam; PF01202; SKI; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..190
FT /note="Probable gluconokinase"
FT /id="PRO_0000327373"
FT BINDING 7..14
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 190 AA; 21540 MW; 83600D6F4B8DC010 CRC64;
MIIVIMGVSG SGKTVVGSQL AKKLGWNFYD ADDYHPLENK EKMSQGTPLN DQDRHPWLCE
LHEIMMREKA LGQHVVLACS ALKRAYRSTL LTGSTPHWPE NYQENDDLSS DTLFVHLHGS
LEILSRRLLE RKGHFMPRTL LDSQIDTLEP PSAPERFIAI DVDKDISVIV SEIEGEVDRK
MMLVKSAQKD
//
