ID GPC5C_BOVIN Reviewed; 442 AA.
AC Q2YDG0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=G-protein coupled receptor family C group 5 member C;
DE Flags: Precursor;
GN Name=GPRC5C;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This retinoic acid-inducible G-protein coupled receptor
CC provide evidence for a possible interaction between retinoid and G-
CC protein signaling pathways. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; BC110241; AAI10242.2; -; mRNA.
DR RefSeq; NP_001258939.1; NM_001272010.1.
DR AlphaFoldDB; Q2YDG0; -.
DR STRING; 9913.ENSBTAP00000062937; -.
DR GlyCosmos; Q2YDG0; 1 site, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000024834; -.
DR GeneID; 535664; -.
DR KEGG; bta:535664; -.
DR CTD; 55890; -.
DR eggNOG; ENOG502QQEH; Eukaryota.
DR InParanoid; Q2YDG0; -.
DR OrthoDB; 4263681at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0070062; C:extracellular exosome; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR CDD; cd15277; 7tmC_RAIG3_GPRC5C; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR PANTHER; PTHR14511:SF15; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER C; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..442
FT /note="G-protein coupled receptor family C group 5 member
FT C"
FT /id="PRO_0000251135"
FT TOPO_DOM 24..50
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..442
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 345
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ84"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ84"
FT MOD_RES 404
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K3J9"
FT MOD_RES 407
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K3J9"
FT MOD_RES 415
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8K3J9"
FT MOD_RES 424
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ84"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 442 AA; 48459 MW; B2A5434AA562DF31 CRC64;
MAIHRTVLMC LGLPLFLLPG ARAQEQAPPG CSPDLNPLYY NLCDRSEAWG IILEAVAGAG
VVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL FCLVFACVVK PSFSTCASRR
FLFGVLFAIC FSCLVAHVLA LHFLVRKNHG PRGWVIFLVA LLLSLVEVII NTEWLIITLV
RGAGTEGDAL GNGSAGWVAV SPCAIANADF VMALIYVMLL LLCAFSGAWS ALCGRFKRWR
KHGVFILLTT TASIAVWVVW IVMYTYGNRQ HNSPTWDDPT LAIALATNAW AFVLFYVIPE
VSQVTRSSPE QSYQGDLYPT RGVGYETILK EQKGQSMFVE NKAFSMDEPA SAKRPVSPYS
GYNGQLLTSM YQPTEMTLMH KAPSDGAYDV ILPRATANSQ VTGSANSTLR AEDIYAAQGR
QEATLPKEGK NSQVFRNPYV WD
//
