ID GSC_PONPY Reviewed; 257 AA.
AC A2T7P4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 22-FEB-2023, entry version 62.
DE RecName: Full=Homeobox protein goosecoid;
GN Name=GSC;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates chordin (CHRD). May play a role in spatial
CC programing within discrete embryonic fields or lineage compartments
CC during organogenesis. In concert with NKX3-2, plays a role in defining
CC the structural components of the middle ear; required for the
CC development of the entire tympanic ring (By similarity). Probably
CC involved in the regulatory networks that define neural crest cell fate
CC specification and determine mesoderm cell lineages in mammals (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ977514; ABM89322.1; -; Genomic_DNA.
DR AlphaFoldDB; A2T7P4; -.
DR BMRB; A2T7P4; -.
DR SMR; A2T7P4; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR GO; GO:0014036; P:neural crest cell fate specification; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR46643:SF2; HOMEOBOX PROTEIN GOOSECOID; 1.
DR PANTHER; PTHR46643; HOMEOBOX PROTEIN GOOSECOID-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..257
FT /note="Homeobox protein goosecoid"
FT /id="PRO_0000285445"
FT DNA_BIND 160..219
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 213..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 28070 MW; A8EA0175420035BE CRC64;
MPASMFSIDN ILAARPRCKD SVLPVAPSAA APVVFPALHG DSLYGASGGA SSDYGAFYPR
PVAPGGAGLP AAVSGSRLGY NNYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPAPSGY
EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ
ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSSKA
SPEKREEEGK SDLDSDS
//
