ID   H0A3B5_9PROT            Unreviewed;       550 AA.
AC   H0A3B5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Thiamine pyrophosphate protein {ECO:0000313|EMBL:EHL99151.1};
GN   ORFNames=HMPREF9946_03307 {ECO:0000313|EMBL:EHL99151.1};
OS   Acetobacteraceae bacterium AT-5844.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae.
OX   NCBI_TaxID=1054213 {ECO:0000313|EMBL:EHL99151.1, ECO:0000313|Proteomes:UP000003292};
RN   [1] {ECO:0000313|EMBL:EHL99151.1, ECO:0000313|Proteomes:UP000003292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AT-5844 {ECO:0000313|Proteomes:UP000003292};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHL99151.1}.
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DR   EMBL; AGEZ01000097; EHL99151.1; -; Genomic_DNA.
DR   AlphaFoldDB; H0A3B5; -.
DR   STRING; 1054213.HMPREF9946_03307; -.
DR   PATRIC; fig|1054213.3.peg.3036; -.
DR   eggNOG; COG0028; Bacteria.
DR   HOGENOM; CLU_013748_3_4_5; -.
DR   OrthoDB; 4494979at2; -.
DR   BioCyc; ABAC1054213:G1H32-3067-MONOMER; -.
DR   Proteomes; UP000003292; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd00568; TPP_enzymes; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF120; ACETOLACTATE SYNTHASE LARGE SUBUNIT; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003292};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..118
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          191..325
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          385..531
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   550 AA;  59317 MW;  AFC82AE7CE6B5C06 CRC64;
     MSARTGGQIL VDQLVAQGVE RVTCVPGESY LAVLDALYDA KIDVLTCRQE GGAAIMAEAY
     GKLTGRPGVC FVTRGPGATN ASHGVHIAMQ DSTPMILFVG QIETGMRERE AFQELDYRAV
     FGSMTKWTTE IDTPDRIPEL VARAFRVAMQ GRPGPVVIAL PEEMLVALAE VPDVPRVEPA
     TPAPAPADVT ALEKLLEGAK KPIAILGGSG WDEAAIDAMA DFADRWSLPV CTSFRRADRF
     RWDHRCYVGD LGIGPSPKLS AMVKEADVLL LIGGRMSEMP SSSYTMIDIP VPQQTLVHVH
     PGAEELGRVY APTIAIPVPP RAFTPALASL SPKGMPAWAD ATAEAHAAYL DWSGKTRKLP
     GDFQYGEVVR WLNENLPADT VLCNGAGNFA GWMHRHWRFS QLGTQLAPTS GSMGYGVPAA
     IMAKRQKPGS TSIVIAGDGD FLMNGQEFAT AVQHDIPFIV IVIDNGMYGT IRMHQERDYP
     GRVSATRLKN PDFAAYAKAF GGHGEVVRRT EEFAPAFQRA VESGKPAILH CFLDPRALSV
     GKDMPEGAPL
//