ID H0A3S2_9PROT Unreviewed; 321 AA.
AC H0A3S2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Putative 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase {ECO:0000313|EMBL:EHL98837.1};
DE Flags: Fragment;
GN ORFNames=HMPREF9946_03481 {ECO:0000313|EMBL:EHL98837.1};
OS Acetobacteraceae bacterium AT-5844.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae.
OX NCBI_TaxID=1054213 {ECO:0000313|EMBL:EHL98837.1, ECO:0000313|Proteomes:UP000003292};
RN [1] {ECO:0000313|EMBL:EHL98837.1, ECO:0000313|Proteomes:UP000003292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AT-5844 {ECO:0000313|Proteomes:UP000003292};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00009553}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHL98837.1}.
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DR EMBL; AGEZ01000110; EHL98837.1; -; Genomic_DNA.
DR AlphaFoldDB; H0A3S2; -.
DR STRING; 1054213.HMPREF9946_03481; -.
DR PATRIC; fig|1054213.3.peg.3188; -.
DR eggNOG; COG0620; Bacteria.
DR HOGENOM; CLU_040013_3_2_5; -.
DR Proteomes; UP000003292; Unassembled WGS sequence.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:EHL98837.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003292};
KW Transferase {ECO:0000313|EMBL:EHL98837.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..314
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHL98837.1"
SQ SEQUENCE 321 AA; 35899 MW; F3FB793C455D7605 CRC64;
PQTAEVRRAR AAHARGALDA AGYDAFLLAE TEAAIRWQEE AGVDVLVHGE FERNDMVKYF
GEQLSGYAFT RHGWVQSYGS RCVAPPIIWG DVSRPQAMTV DWWKRAQAMT SRPVKGMLTG
PVTMLHWSFV RDDLPKETVC RQIALALRDE VVELEAAGCA IIQIDEPAFR EGLPLRKADH
AEYLRWAVEC FRLSACGVAD ETQIHTHMCY AEFNDIIAAI AAMDADAISI ETARSRMELL
EAFESFDYPN AIGPGVWDIH SPRVPQADEM TTLLRRATQS IPAERLWVNP DCGCKTRGWA
EVRPAMANLV EAARQLRAEL V
//
