ID H0PWP6_9RHOO Unreviewed; 664 AA.
AC H0PWP6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Alpha-subunit of fatty acid oxidation complex {ECO:0000313|EMBL:BAL26545.1};
GN Name=fadB {ECO:0000313|EMBL:BAL26545.1};
GN ORFNames=AZKH_4266 {ECO:0000313|EMBL:BAL26545.1};
OS Azoarcus sp. KH32C.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Azoarcus.
OX NCBI_TaxID=748247 {ECO:0000313|EMBL:BAL26545.1, ECO:0000313|Proteomes:UP000007106};
RN [1] {ECO:0000313|EMBL:BAL26545.1, ECO:0000313|Proteomes:UP000007106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KH32C {ECO:0000313|EMBL:BAL26545.1,
RC ECO:0000313|Proteomes:UP000007106};
RA Nishizawa T., Tago T., Oshima K., Hattori M., Ishii S., Otsuka S.,
RA Senoo K.;
RT "Complete genome sequence of Azoarcus sp. KH32C.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; AP012304; BAL26545.1; -; Genomic_DNA.
DR RefSeq; WP_015437845.1; NC_020516.1.
DR AlphaFoldDB; H0PWP6; -.
DR STRING; 748247.AZKH_4266; -.
DR KEGG; aza:AZKH_4266; -.
DR PATRIC; fig|748247.4.peg.4224; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_16_1_4; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000007106; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000007106}.
FT DOMAIN 308..482
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 486..576
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 664 AA; 70629 MW; 4277DBC8CA77E335 CRC64;
MSPDFKHLVL VRKGDADGLA WLYLDRAGAS TNTLSRELLD ELAGAFAALE ADPPKGLIIA
SAKPAGFVAG ADIEEFTRID SAEGARDLVQ RGWELFNWLA RLKFPTLALI RGHCLGGGLE
LALACRYRIV VDEPGTKLAL PEVMLGIVPG WGGMKRLPAL VGPAAALDMM LTGKGIDARR
AKQMGLADEC VPPRVMENAA RMVVLSGQRP RALPFMQRLL NGPLKAVVAA GARKQVAVKA
SREHYPAPYA IVDIWQKYGG NALAVPADHP ASLEAIFRSP TAKNLVRVFF LQERLKGFGK
DSDFAPRHVH VVGAGVMGGD IAALCAFSGL TVTLQDQSVE RIAPAIARAA KLYERKFRGD
RRQVRFALDR LIPDPEGHGA ARADVVIEAI FENLEAKRAL FAELERKAKP GAVLATNTSS
LRIEDIATGL SDPRRLVGIH FFNPVALMPL VEVVRGEQSD DEALRRAAAF VRRLDKLPLP
VKSAPGFLVN AVLGPYMLEA LRCVDEGIAP ETVDAALLAF GMPMGPVELV DTVGLDIAVA
AGRALAGLGA EPPRKLLELV GAGHLGKKTG QGYYRWADGK PQKGAAGAVP DGLVQRIVGP
LLAATRRCVE QGVVADADLA DAGVIFGTGF APFTGGPLHF SPIMGKSVRG ADARLADGAM
VEAR
//