ID   H0Q4E8_9RHOO            Unreviewed;       521 AA.
AC   H0Q4E8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=AZKH_3703 {ECO:0000313|EMBL:BAL25987.1};
OS   Azoarcus sp. KH32C.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Azoarcus.
OX   NCBI_TaxID=748247 {ECO:0000313|EMBL:BAL25987.1, ECO:0000313|Proteomes:UP000007106};
RN   [1] {ECO:0000313|EMBL:BAL25987.1, ECO:0000313|Proteomes:UP000007106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KH32C {ECO:0000313|EMBL:BAL25987.1,
RC   ECO:0000313|Proteomes:UP000007106};
RA   Nishizawa T., Tago T., Oshima K., Hattori M., Ishii S., Otsuka S.,
RA   Senoo K.;
RT   "Complete genome sequence of Azoarcus sp. KH32C.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; AP012304; BAL25987.1; -; Genomic_DNA.
DR   RefSeq; WP_015437289.1; NC_020516.1.
DR   AlphaFoldDB; H0Q4E8; -.
DR   STRING; 748247.AZKH_3703; -.
DR   KEGG; aza:AZKH_3703; -.
DR   PATRIC; fig|748247.4.peg.3665; -.
DR   eggNOG; COG2202; Bacteria.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_522395_0_0_4; -.
DR   OrthoDB; 5389366at2; -.
DR   Proteomes; UP000007106; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007106}.
FT   DOMAIN          88..142
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          146..190
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          219..271
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          291..518
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   521 AA;  56568 MW;  01557DE1C31B2A6D CRC64;
     MSEQLRFLDE SADLRCLEPI FEAMVEGMVV RDVRGRVIVA NAAARRILGP GMLAGQGSFA
     HRTGAADANE AASRTEEQLA MATLHGGEPQ RAVLLELCGA AGRVWIQANA QPIFGAGGGI
     AGVLTTFSDI TPMKLAEEAL RLSEGRNRTL AEAIAQSGCA VIVTDPSGRI EFVNSACCKA
     YGYSQEELLG ASPSIFKSGE TPREVYEALW RTILAGDVWR GELSNRARDG RLIREAVSVS
     PVRDELGEIR HFVALKEDIT PLREEERRRH ELFERVARLE RMELVATLAG GIAHDFNNVL
     VAILGYSELA DRMLKADGRL PRVAGYIDEI RIAGARARDL IQQLLNFSRS GVVQPRLTRL
     EDIGREAVGL LRATLPDTVA LIPDIDPALP DMSFDPAHLH QIVMNLLMNA RDAVNGKGTI
     RLSARRVSVG GAECCDSCRR EFSGDYVAIT VADDGVGISA EHRLHLFEPF FTTKEIGRGT
     GMGLAVVHSM AHLYDGHVKV VSTPGQGCAI TVLMPVVRHQ D
//