ID H0QHM0_ARTGO Unreviewed; 1354 AA.
AC H0QHM0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ARGLB_012_00150 {ECO:0000313|EMBL:GAB12321.1};
OS Arthrobacter globiformis NBRC 12137.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1077972 {ECO:0000313|EMBL:GAB12321.1, ECO:0000313|Proteomes:UP000003828};
RN [1] {ECO:0000313|EMBL:GAB12321.1, ECO:0000313|Proteomes:UP000003828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12137 {ECO:0000313|EMBL:GAB12321.1,
RC ECO:0000313|Proteomes:UP000003828};
RA Miyazawa S., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Arthrobacter globiformis NBRC 12137.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB12321.1}.
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DR EMBL; BAEG01000012; GAB12321.1; -; Genomic_DNA.
DR RefSeq; WP_003798297.1; NZ_BAEG01000012.1.
DR STRING; 1077972.ARGLB_012_00150; -.
DR eggNOG; COG1002; Bacteria.
DR OrthoDB; 4280289at2; -.
DR Proteomes; UP000003828; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000003828};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 505..585
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT REGION 1332..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1354 AA; 149455 MW; EF0CF1ED07339B6F CRC64;
MSAAFQAITV VGGVVPPSLL GRVQAGEVND ARSMAPASFH LAGTETVRDA ASRTWMYLQG
AWRAWRESDA TKRPDGQGAG TGDARQKWLL VLLRELGYGQ VPATPGGLTI GGEAYPISHR
WESVPIHLLG PGVDLDKRTP KVEGAARRAP QAMMQEFLNR EDTYLWAILS NGLRLRLLRD
STALAGSAYI EFDLETIFES DLYSEFQLFW QLCHQSRLDK RGGSESPPSD CWLELWRGES
VEAGARALDK LGAGVEKALD FLGSGFLRHP DNRWLVDALH SGDLSHRDFH KALLRTAYRL
LFIFVVEDRG ALLDPAATTE ARHRYETYFS TQRLRKMSRT RDGGPHPDLW RTQKLVLGAL
GGEGLGVIGL PALGGLFDPD PRAARLAGQP HGDLLLGAEL ANQDFLKAIR VLGWVAGKTG
RLQPVDYRHL GAEELGSVYE SLLELVPRVD TETRSFELAH LAGNERKTTG SYYTPPSLVS
ALLDTALDPL LDQAVNGAAG RDDAEARLLA LTVCDPASGS GGFLVAAARR IARRLAEVRA
GENEPTPGEV QSALHDVVER CIYGVDMNDL AAELAKVSLW LEAMQPGKPL GFLDARIKIG
NSLLGTTPAL LAGGVPDEAF GVLDGDDAKY SAEIKKRNRL ENARSSPGSR FKHGGQDSFN
FAPPVAGISA LIGQRRELVK PVYSAAEARD RAAAYAAFDH SRDMEQRRLH ADAWCAAFVW
PLITEEAEPP TSALVRQLGE ADELSGHSET VAMVRHLSEE YRFFHWHLEF PEVFGDPQSA
DASVERWPKG FSCMLGNPPW EKIKLQEKEF FGARDARVAN AKTASERRSL IRDLAKTDVG
TSLLSEYNRS RRQSEAFSFF VRKSGRFPLG GRGDVNTYTV FTELFSQIVS PSGRAGVIVK
TGIATDDTTK ELFQALSDEA RVLSLFDFEN TQSGGGRYFV GAHASERFSL LTILGQQSRA
EKMRIGFMIS HPDKIALESY FLLPSDIKLM NPISGTLPVF KAQRDVDITR EIYGRVPIFK
SGAWGEIAYD RMFDVTNDSG HFRSAASLET GDFTMRSDGN LVSDGKMVVR VYEGKMVSHW
DHRNADVVWS QAAVHRQRQP KYISENEKSN PERLAVPGYW VDHPLVPAAA RSWQIGFASV
TAPKNQRTFS VAPVPPAAAT NSLPLIRIDQ PTGMRLCLLA NLSSFVFDYV ARQKVGGVNM
NFFIVDQLPV LSPQEYSRPV AWDTSVSYER WISDRAYELV FTANDMQSVG HELGDQRGPF
SWIPARRRII SAELDAAYFH LYGLDRDTVG YVMDTFNVTR RVDAASFGDY RTKMQILEVF
EAMQDAIKTG VPYESALTPP PGQGPRHPAK EISA
//
