ID   H0QKD6_ARTGO            Unreviewed;       787 AA.
AC   H0QKD6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   13-SEP-2023, entry version 51.
DE   SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:GAB13376.1};
GN   Name=pdxA {ECO:0000313|EMBL:GAB13376.1};
GN   ORFNames=ARGLB_037_02270 {ECO:0000313|EMBL:GAB13376.1};
OS   Arthrobacter globiformis NBRC 12137.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=1077972 {ECO:0000313|EMBL:GAB13376.1, ECO:0000313|Proteomes:UP000003828};
RN   [1] {ECO:0000313|EMBL:GAB13376.1, ECO:0000313|Proteomes:UP000003828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12137 {ECO:0000313|EMBL:GAB13376.1,
RC   ECO:0000313|Proteomes:UP000003828};
RA   Miyazawa S., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Arthrobacter globiformis NBRC 12137.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the four-carbon acid sugar kinase family.
CC       {ECO:0000256|ARBA:ARBA00005715}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB13376.1}.
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DR   EMBL; BAEG01000037; GAB13376.1; -; Genomic_DNA.
DR   AlphaFoldDB; H0QKD6; -.
DR   STRING; 1077972.ARGLB_037_02270; -.
DR   eggNOG; COG1995; Bacteria.
DR   eggNOG; COG3395; Bacteria.
DR   OrthoDB; 9801783at2; -.
DR   Proteomes; UP000003828; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.980.20; Four-carbon acid sugar kinase, nucleotide binding domain; 1.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   Gene3D; 3.40.50.10840; Putative sugar-binding, N-terminal domain; 1.
DR   InterPro; IPR010737; 4-carb_acid_sugar_kinase_N.
DR   InterPro; IPR037051; 4-carb_acid_sugar_kinase_N_sf.
DR   InterPro; IPR031475; NBD_C.
DR   InterPro; IPR042213; NBD_C_sf.
DR   InterPro; IPR005255; PdxA_fam.
DR   NCBIfam; TIGR00557; pdxA; 1.
DR   PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR   Pfam; PF17042; NBD_C; 1.
DR   Pfam; PF04166; PdxA; 1.
DR   Pfam; PF07005; SBD_N; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   SUPFAM; SSF142764; YgbK-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003828};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          5..237
FT                   /note="Four-carbon acid sugar kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07005"
FT   DOMAIN          270..417
FT                   /note="Four-carbon acid sugar kinase nucleotide binding"
FT                   /evidence="ECO:0000259|Pfam:PF17042"
SQ   SEQUENCE   787 AA;  79844 MW;  F4E3CB7397D58ABC CRC64;
     MTVVLIQADD FSGAAEVGQC FAAQGLDTRL LLSAPAADTT AEGAATAADA GGRPDVVVVD
     THSRAVSPES AAAAAAAVFG SPAADGAGVL FKKIDSLWRG NVGPELAALS ALGHHIVVAG
     ALPQLNRTVV GGRPFADGVR LDRTELWRAE AAAPPAEIAE LLGPGSAVQL AGLSAVRSGG
     LAAVLGEALS VSSAAPATVI VDGETPADLE AVADALLDLE FRAGGRRIVL AGTGGMALLL
     AAKLGSSSAR NAQQQVSPGL TTAGGPRTVL AAVGSASEKA AAQLRNLEAG GFTTLRLASG
     ELQRPEDSGP RLAEARQLLA AGEPAALTVT AGVVNPDESG RIVQNLARLA ASAAAGPATA
     ADLILTGGET AREVLDALGV RSLTPLASVQ HGAVVSLSDD GRLVGTKPGS FGDDNALVQL
     YSAIKDLRSS NSTSHPSLTP GAPMTSAVNA TEQQDTRPFI AVTMGDGAGV GPEVTVGALL
     DGNAYRDCRP VVVGDVHRLQ LGAKALGVEA NIVEVETVGE AVFEAGRINV IDPKLLSADL
     PWGQESAEAG NAAYHYIRIA CELGMGGQVQ GICTAPLNKA ALHKAGHIYP GHTELLAHFM
     GVEEVSMMLS TPKVKVIHVT THIGLIDAIN KIEPGLVERT VRRGHSAMQR AGIANPKIGV
     CAINPHAGEN GLFGYGEEAE KITPAIEKLQ ADGIDAVGPL PADTAFFLAG RGDYDLIVAM
     YHDQGHGPVK VLGIEAGVNI TVGLPVIRTS VDHGTAFDIA GKGIVDVRSM IEALRQAAEM
     SPSPAAA
//