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Database: UniProt
Entry: H0QWS6_9ACTN
LinkDB: H0QWS6_9ACTN
Original site: H0QWS6_9ACTN 
ID   H0QWS6_9ACTN            Unreviewed;       508 AA.
AC   H0QWS6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:GAB17277.1};
GN   ORFNames=GOEFS_022_00580 {ECO:0000313|EMBL:GAB17277.1};
OS   Gordonia effusa NBRC 100432.
OC   Bacteria; Actinobacteria; Corynebacteriales; Gordoniaceae; Gordonia.
OX   NCBI_TaxID=1077974 {ECO:0000313|EMBL:GAB17277.1, ECO:0000313|Proteomes:UP000035034};
RN   [1] {ECO:0000313|EMBL:GAB17277.1, ECO:0000313|Proteomes:UP000035034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100432 {ECO:0000313|EMBL:GAB17277.1,
RC   ECO:0000313|Proteomes:UP000035034};
RA   Yoshida I., Takarada H., Hosoyama A., Tsuchikane K., Katsumata H.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia effusa NBRC 100432.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAB17277.1}.
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DR   EMBL; BAEH01000022; GAB17277.1; -; Genomic_DNA.
DR   RefSeq; WP_007316615.1; NZ_BAEH01000022.1.
DR   EnsemblBacteria; GAB17277; GAB17277; GOEFS_022_00580.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000035034; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035034};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035034}.
FT   DOMAIN      200    329       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      413    481       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     208    215       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   508 AA;  57169 MW;  4157AE174B8689C0 CRC64;
     MTSERESFSE VWARVVAELN ANSDAIDHQP LTRQQKAWLS LVHPLTLAEG FALLTVPTPL
     VQEQIERTLR EPIRSALSRH LGQPVELGVR IAPPTEESTP ASGEPAPTVF DAPQAEQTSQ
     ATGINDHPER RHFSGRDEPD ANTRGDWSTY FSNETPDTSM TGPTARSLHP RYTFDTFVIG
     ASNRFAHASA VAVSEAPARA YNPLFIWGES GLGKTHLLHA AGHYAQRLFP GMRVKYVSTE
     EFTNDFINSL RDDRRVAFKR RYRDDIDILL VDDIQFLMGR EGIQEEFFHT FNTLHNSGKQ
     IVISSDRPPR QLATLEDRLR TRFEWGLITD VQPPDLETRV AILRKKAQMD DITVPDDVLE
     LIASKIERNI RELEGALIRV TAFASLNNTE LDRSLAEVVL QALLPETNAF EVSAARILTT
     TADYFDLSVD ELRGPSRTRA IAQARQIAMY LCRELTDLSL PKIGETFDRD HTTVIHADKK
     IRGAMAERRD VYNHVQELTA RIKQGAEG
//
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