ID H0UPX2_9BACT Unreviewed; 765 AA.
AC H0UPX2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CRISPR-associated endonuclease Cas3-HD {ECO:0000313|EMBL:EHM10681.1};
GN ORFNames=TheveDRAFT_1563 {ECO:0000313|EMBL:EHM10681.1};
OS Thermanaerovibrio velox DSM 12556.
OC Bacteria; Synergistota; Synergistia; Synergistales; Synergistaceae;
OC Thermanaerovibrio.
OX NCBI_TaxID=926567 {ECO:0000313|EMBL:EHM10681.1};
RN [1] {ECO:0000313|EMBL:EHM10681.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12556 {ECO:0000313|EMBL:EHM10681.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Brambilla E.-M., Klenk H.-P.,
RA Eisen J.A.;
RT "The Noncontiguous Finished genome of Thermanaerovibrio velox DSM 12556.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CM001377; EHM10681.1; -; Genomic_DNA.
DR AlphaFoldDB; H0UPX2; -.
DR STRING; 926567.TheveDRAFT_1563; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_010123_2_0_0; -.
DR Proteomes; UP000005730; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:EHM10681.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000313|EMBL:EHM10681.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 8..184
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 240..437
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 765 AA; 86316 MW; D8F9B3054AACC5D5 CRC64;
MKGWLSGLGT LRQNLAIEIG GNVLGFWHDL GKFLPAWQGY IRKETGYDVE AHLETLGGKV
QHSRAGAVLA FKKLRKCPAV ARVLAYPIAG HHTGLPDWDY ESAGGETLQE RIFDPRDLNP
DEKKLETRDI DQIEREPQAI EFLDKPIPKS APMSVEKPLR GKPRESLHLW VRMLFSCLVD
ADYLDTESFM DRDKSLERSG YASLAELKDR FDRYIDYKQR HAKDTLINRR RREILSKCRQ
KAELEPGIFT LTVPTGGGKT LSSMAFALEH ALAHGKRRIV YAIPYTSIIE QTAKVFKYGT
DRDEEIEEMV NRGVPGLFGE ENVLEHHSNL DPDRESPRSR LAAENWDAPI IVTTNVQFFE
SLFACKPSSC RRLHNIVNSI VILDEAQLLP PEFLRPILSV MRSLVDHFGV TFVLCTATQP
ALTGKIGAGQ AEFEGLDGTV EIIDTPPGSD DAFRRVSFHF PDAKKLERRE WADLAEELSQ
FDQVLCIVNT RRDCRDLCAL MPEGTLHLSA LMCGEDRSDV INVIKNKLKS GEPLRVVSTQ
LVEAGVDIDF PVVYRAMAGL DSIVQAAGRC NREGRLNSSG KLGRVVVFNP PKPAPPGLLR
KGEEACLEIL AKGDLMDLSG SVFGEYFRVF YARVNELDKP KFADRLVSRA SEFKFQFRSL
AQDFSMIDDQ GQRSVVVFYQ SPFNAKRSSR LLIEELRHKG PSRTLFRKLQ RFAVNLRKRE
FEMILRGGMV EEIHGLYVQC CDGLYKPGLG LLVDPSQWSD EVLFA
//
