ID H0UT52_CAVPO Unreviewed; 1394 AA.
AC H0UT52;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Roundabout guidance receptor 3 {ECO:0000313|Ensembl:ENSCPOP00000000072.3};
GN Name=ROBO3 {ECO:0000313|Ensembl:ENSCPOP00000000072.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000072.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000072.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000072.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02024661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000000072; -.
DR Ensembl; ENSCPOT00000000082.3; ENSCPOP00000000072.3; ENSCPOG00000000081.4.
DR VEuPathDB; HostDB:ENSCPOG00000000081; -.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000155457; -.
DR HOGENOM; CLU_003227_5_1_1; -.
DR InParanoid; H0UT52; -.
DR OMA; LMMSHTH; -.
DR TreeFam; TF351053; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000081; Expressed in frontal cortex and 5 other cell types or tissues.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF37; ROUNDABOUT GUIDANCE RECEPTOR 3; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1394
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013130483"
FT DOMAIN 65..254
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 259..343
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 348..441
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 452..532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 559..653
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 673..767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 772..868
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 542..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1394 AA; 148416 MW; FF56C4A0C47E1CF6 CRC64;
MLRYLLKTLL QMNLFADSLA GNVSNSSELL FGGFNSSLAA LNHSLLPPGD PAVNVSRVEP
EDAMPRIVEQ PPDLLVSRGE PATLPCRAEG RPRPNIEWYK NGARVATARE DPRAHRLLLP
SGALFFPRIX XXXXXXXXXX XXXXXXXXXX XXXASRNASL EVAVLREDFR QSPGNAVVAV
GEPAVMECVP PRGHPEPSVT WKKDSARLKE EEGRITIRGG KLMMSHTLKS DAGMYVCVAS
NMAGERESGA AQLVVLERPS FLRKPANQVV LADAPVNFLC EVQGDPPPHL RWRKEDGELP
TGRYEIRSDH SLWIGRVRAE DEGTYTCVAE NSVGRVEASG SLSVHVPPQL VTQPQDQMAA
PGDDVVFQCE TKGNPPPAIF WQKEGSQVLL FPNQSLQPTG RISVSPRGQL NITEVQSGDA
GYYVCQAVSV AGSILAKALL EIKGASLDGL PPVILQGPAN QTLALGSSVW LPCRVSGSPQ
PRVQWKKDGQ WLQGDDLQFS LMANGTLYIA RVQETDMGFY SCVARSSIGE ATWGGWLRKQ
EDWGASLDPP TEHGTPPGPP SQPVVTEITK SSITLTWKPN PQAGATVTSY VIEAFSQAAG
NTWRTVADGV QLETHTVSGL QPNTIYLFLV RAVGAWGLSE PSPVSKPVRT KDSNPSRPVE
DPWRGQQGLA EVAVRMQEPR VLAARTLQVS WTVDGPVQLV QGFRVSWRVA GPDGGSWTVL
DLQTPSQQST VLRGLLPGTQ VQIKVQAHGH EGLGPESPFV TWSVPEEAPS GPPQGVTVAL
GGDGNSSITV SWEPPLPSQQ NGAITEYQIW CLGSDSRFHL NRSAAGWARS ATLRGLRPGL
LYRTLVAAAT SAGVGVASAP VSVQLPSPPG LEPGLEVGRG PAERLARVLR EPAFLAGSGA
ACGALLLGLC AALYRRQKHR KELSHYAASF AYTPAVSFPH SEGLSGASSR PPIGLGSAPY
SWLADSWPHP SSGSPAAQEP RGSCCPSNPD PEDRYYNEAG ISLYLAQTAR GTAAAAEASV
YSTIDLAGEE LQTFHGGFPQ HSSGDPGTWS QYAPPEWSQG DGGARGGKVK LLGKAVQMPS
LNWAEGLPPP PPSCELGCPE GPEEEMEGSS ESEEWCPPMP ERSHLTELSS SGGCRMAPSP
GESPSPTPSY GQQSTATLTP SPPDPPLPPS DIPHLHQMPR RAPLGPSSPL SVSQPTLSSH
EGRPTGLGAG PTASHHLSPS PIPSTTSSTP GRALQVPGEM TPPPQGPRAR IRKKPKALPY
RRERSPGDLP PPPLPPPEEE VGWTLGLRAA GSLSSLERKG SGERRVLQAV PPGTQSGPHQ
EATLLCCTAE GAWLPCSRPS FLSRGQGTST CSTAGSNSSR GSGSSRGSRG PGRSRSRSRS
HSQRPGQKRQ EEPR
//
