ID H0UTJ4_CAVPO Unreviewed; 589 AA.
AC H0UTJ4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit {ECO:0000256|PIRNR:PIRNR028043};
GN Name=PPP2R5C {ECO:0000313|Ensembl:ENSCPOP00000000234.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000234.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000234.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000234.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC and catalytic activity, and also might direct the localization of the
CC catalytic enzyme to a particular subcellular compartment.
CC {ECO:0000256|PIRNR:PIRNR028043}.
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56
CC family. {ECO:0000256|ARBA:ARBA00009745}.
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DR EMBL; AAKN02051974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02051975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UTJ4; -.
DR STRING; 10141.ENSCPOP00000000234; -.
DR Ensembl; ENSCPOT00000000268.3; ENSCPOP00000000234.3; ENSCPOG00000000265.4.
DR VEuPathDB; HostDB:ENSCPOG00000000265; -.
DR eggNOG; KOG2085; Eukaryota.
DR GeneTree; ENSGT01030000234620; -.
DR HOGENOM; CLU_012437_3_2_1; -.
DR InParanoid; H0UTJ4; -.
DR OMA; MRKHINN; -.
DR TreeFam; TF105556; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000265; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:UniProtKB-UniRule.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002554; PP2A_B56.
DR PANTHER; PTHR10257; SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B; 1.
DR PANTHER; PTHR10257:SF19; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM; 1.
DR Pfam; PF01603; B56; 1.
DR PIRSF; PIRSF028043; PP2A_B56; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 15..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 68311 MW; D1A1EFE4867F13B4 CRC64;
MGRWRFRITL KSSFLGFKDP PKAGKSGKSS KEGQDPVESE QISSRKNNVL AVQSSTSAKI
KATPPPQPMA KKDKRPNSSR FNSSNNRELQ KLPSLKDVPP ADQEKLFTQK LRQCCVLFDF
VSDPLSDLKW KEVKRAALSE MVEYITHNRN VITEPIYPEV VHMFAVNMFR TLPPSSNPTG
AEFDPEEDEP TLEAAWPHLQ LVYEFFLRFL ESPDFQPNIA KKYIDQKFVL QLLELFDSED
PRERDFLKTT LHRIYGKFLG LRAYIRKQIN NIFYRFIYET EHHNGIAELL EILGSIINGF
ALPLKEEHKI FLLKVLLPLH KVKSLSVYHP QLAYCVVQFL EKDSTLTEPV VMALLKYWPK
THSPKEVMFL NELEEILDVI EPSEFVKIME PLFRQLAKCV SSPHFQVAER ALYYWNNEYI
MSLISDNAAK ILPIMFPSLY RNSKTHWNKT IHGLIYNALK LFMEMNQKLF DDCTQQFKAE
KLKEKLKMKE REEAWVKIEN LAKANPQYTV YSQASTMSLP VAMETDGPLF EDVQMLRKTV
SDEVHQAQKD LKKDRPLARR KSELPQDPHT KKALEAHCRA DALASQDGR
//
