ID H0UTU4_CAVPO Unreviewed; 767 AA.
AC H0UTU4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=SRY-box transcription factor 30 {ECO:0000313|Ensembl:ENSCPOP00000000348.3};
GN Name=SOX30 {ECO:0000313|Ensembl:ENSCPOP00000000348.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000348.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000348.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000348.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02022578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003473352.1; XM_003473304.1.
DR AlphaFoldDB; H0UTU4; -.
DR STRING; 10141.ENSCPOP00000000348; -.
DR Ensembl; ENSCPOT00000000400.3; ENSCPOP00000000348.3; ENSCPOG00000000397.4.
DR GeneID; 100728157; -.
DR KEGG; cpoc:100728157; -.
DR CTD; 11063; -.
DR VEuPathDB; HostDB:ENSCPOG00000000397; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000161042; -.
DR HOGENOM; CLU_021249_0_0_1; -.
DR InParanoid; H0UTU4; -.
DR OMA; FIPSPAY; -.
DR OrthoDB; 2902801at2759; -.
DR TreeFam; TF336594; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000397; Expressed in testis.
DR GO; GO:0010369; C:chromocenter; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0120211; P:proacrosomal vesicle fusion; IEA:Ensembl.
DR GO; GO:0031960; P:response to corticosteroid; IEA:Ensembl.
DR CDD; cd22033; HMG-box_SoxH_SOX30; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR47279; TRANSCRIPTION FACTOR SOX-30; 1.
DR PANTHER; PTHR47279:SF1; TRANSCRIPTION FACTOR SOX-30; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 351..419
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 351..419
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 83202 MW; B5ADB141177FAF43 CRC64;
METARPEPPP QPRQLPRATP PRPLRPAPPS LPVEGTSFRA AASKPSPSPP APCAAAIVTV
ASSCGEAPAL GVQPRTQRLI QVKPEQVLLL PQAPLLSQVQ DEGGPAPPAQ AQAQAQARLL
QLRPELLLLP PVSEGAPYRP ELLAVQPQAP QVKAEKPEVG HNLEPSVGHL RVVEAGPRAS
TVATVDGHGL ALDSLRGDEN KGKLGAEEVM KDAVRPGEGK SLAAIGDGII KTEEREDCRL
GTEPASNGLV HGNKEVILAQ PSSAFGLQQQ DLRIPLTLHP VPPGTRIQFQ GPPPSDLIRL
TKVPLTPVPI KMQSLLEPSV KIETKDVPLT VLPSDAGIPD TPFSKDRNGH VKRPMNAFMV
WARIHRPALA KANPAANNAE ISVQLGLEWN KLSEEQKKPY YDEAQKIKEK HREEFPGWVY
QPRPGKRKRF PLSVSSVFSG TTQNIISTNP TTIYPYRSPT YSVVIPSLQN TITHPVGEAP
PAIQLPTPAV QRPSPITLFQ PSVSNNAQVA VQAPSLPLHP AAPPQRFPGP SQADTHLLPS
GPSHSVKRPT PVSLESTNSI STSASTANAR FATPAIQPPK EYTSVSACPR SAPVPQAPPM
PHSHVYQPPP LGHPATLFGT PPRFSFHHPY FLPGPHYFPS STCPYSRPPF GYGNFPSSMP
ECLGYYEDRY QKHESMFSAL NRDYPFRDYP DEHTHSEDSR SCESIDGTSY YNSHSHSGEE
YLNPIPQLDI GTLENVFTAP TSTPSSIQQV NVTDSDEEEE EKVLRNL
//
