ID H0UTU5_CAVPO Unreviewed; 331 AA.
AC H0UTU5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Rho guanine nucleotide exchange factor 39 {ECO:0000313|Ensembl:ENSCPOP00000000349.3};
GN Name=ARHGEF39 {ECO:0000313|Ensembl:ENSCPOP00000000349.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000349.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000349.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000349.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02030431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UTU5; -.
DR STRING; 10141.ENSCPOP00000000349; -.
DR Ensembl; ENSCPOT00000000401.3; ENSCPOP00000000349.3; ENSCPOG00000000398.4.
DR VEuPathDB; HostDB:ENSCPOG00000000398; -.
DR eggNOG; ENOG502QTR5; Eukaryota.
DR GeneTree; ENSGT00440000033863; -.
DR HOGENOM; CLU_052525_0_0_1; -.
DR InParanoid; H0UTU5; -.
DR OMA; EHAYPLQ; -.
DR TreeFam; TF350447; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000398; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR042987; ARHGEF39.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47056; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR PANTHER; PTHR47056:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 22..197
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 227..331
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 331 AA; 37735 MW; 36D0E78D19060EA6 CRC64;
MASPGPGSRC PLLEQRARWE RKRACTAREL LETERRYLEQ LELVATYFLG ILKAKGTLRP
PERQSLFGCW ELIYGASQEL LPYLEGGHWG RGLEGFCTHL ELYVQFAANA ERSQTTLQEQ
LKKNKRFRKF VRLQEGRPQF GGLQLQDLLP LPLQRLQQYE NLVVALAENT VPNSPDHQQL
TRAARLISET AQRVHTIGQE QKNDQHLRRI QALLSGRQAK GLTSGRWFLH QGWLLVVPPT
GEPRPRMFFL FSDVLLMAKP RPALHLLKSG TFACRALYPM AQCQLCRVFG HSGGPCGGLL
SLSFPNEKLL LMSTDQKELS HWYQSLALAI R
//
