ID H0UUU6_CAVPO Unreviewed; 811 AA.
AC H0UUU6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=DNM3 {ECO:0000313|Ensembl:ENSCPOP00000000751.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000751.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000751.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000751.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; AAKN02017804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02017813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UUU6; -.
DR STRING; 10141.ENSCPOP00000000751; -.
DR Ensembl; ENSCPOT00000000842.3; ENSCPOP00000000751.3; ENSCPOG00000000836.4.
DR VEuPathDB; HostDB:ENSCPOG00000000836; -.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000158056; -.
DR HOGENOM; CLU_008964_3_3_1; -.
DR InParanoid; H0UUU6; -.
DR OMA; NTIKKCT; -.
DR TreeFam; TF300362; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000836; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF54; DYNAMIN-3; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 14..280
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 501..607
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 588..692
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 690..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..768
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 91381 MW; 3B105B9AF6FCC133 CRC64;
RLQDAFSALG QTCLLELPQI AVVGGQSAGK SSVLENFVGR DFLPRGSGIV TRRPLVLQLV
TSKAEYAEFL HCKGKKFTDF DEVRHEIEAE TDRVTGMNKG ISPIPINLRV YSPHVLNLTL
IDLPGITKVP VGDQPPDIEY QIREMIMQFI TRENCLILAV TPANTDLANS DALKLAKEVD
PQGLRTIGVI TKLDLMDEGT DARDVLENKL LPLRRGYVGV VNRSQKDIDG KKDIKAAMLA
ERKFFLSHPA YRHIADRMGT PHLQKVLNQQ LTNHIRDTLP NFRNKLQGQL LSIEHEVEAY
KNFKPEDPTR KTKALLQMVQ QFAVDFEKRI EGSGDQVDTL ELSGGAKINR IFHERFPFEI
VKMEFNEKEL RREISYAIKN IHGIRTGLFT PDMAFEAIVK KQIVKLKGPS LKSVDLVMQE
LINTVKKCTK KLANFPRLCE ETERIVANHI REREGKTKDQ VLLLIDIQVS YINTNHEDFI
GFANAQQRSS QVHKKTTIGN QVIRKGWLTI SNIGIMKGGS KGYWFVLTAE SLSWYKDDEE
KEKKYMLPLD NLKVRDVEKS FMSSKHIFAL FNTEQRNVYK DYRFLELACD SQEDVDSWKA
SLLRAGVYPD KSLTENDENG QTENFSMDPQ LERQVKDFIN SELLAQLYSS EDQNTLMEES
AEQAQRRDEM LRMYQALKEA LVIIGDINTA TVSTPAPPPV DDSWIQHSRR SPPPSPTTQR
RPTLSTPLTR PTSGRGPAPA IPSPGPHSGA PPVPFRPGPL PPFPNSSDSF GAPPQVPSRP
TRAPPSVPSR RPPPSPTRPT IIRPLESSLL D
//