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Database: UniProt
Entry: H0UUU6_CAVPO
LinkDB: H0UUU6_CAVPO
Original site: H0UUU6_CAVPO 
ID   H0UUU6_CAVPO            Unreviewed;       811 AA.
AC   H0UUU6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE            EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN   Name=DNM3 {ECO:0000313|Ensembl:ENSCPOP00000000751.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000751.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000000751.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000751.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001837};
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR   EMBL; AAKN02017804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02017813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0UUU6; -.
DR   STRING; 10141.ENSCPOP00000000751; -.
DR   Ensembl; ENSCPOT00000000842.3; ENSCPOP00000000751.3; ENSCPOG00000000836.4.
DR   VEuPathDB; HostDB:ENSCPOG00000000836; -.
DR   eggNOG; KOG0446; Eukaryota.
DR   GeneTree; ENSGT00940000158056; -.
DR   HOGENOM; CLU_008964_3_3_1; -.
DR   InParanoid; H0UUU6; -.
DR   OMA; NTIKKCT; -.
DR   TreeFam; TF300362; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000000836; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   CDD; cd08771; DLP_1; 1.
DR   CDD; cd01256; PH_dynamin; 1.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF54; DYNAMIN-3; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00410; G_DYNAMIN_1; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   GTP-binding {ECO:0000256|RuleBase:RU003932};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN          14..280
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          501..607
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          588..692
FT                   /note="GED"
FT                   /evidence="ECO:0000259|PROSITE:PS51388"
FT   REGION          690..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..768
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        777..800
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   811 AA;  91381 MW;  3B105B9AF6FCC133 CRC64;
     RLQDAFSALG QTCLLELPQI AVVGGQSAGK SSVLENFVGR DFLPRGSGIV TRRPLVLQLV
     TSKAEYAEFL HCKGKKFTDF DEVRHEIEAE TDRVTGMNKG ISPIPINLRV YSPHVLNLTL
     IDLPGITKVP VGDQPPDIEY QIREMIMQFI TRENCLILAV TPANTDLANS DALKLAKEVD
     PQGLRTIGVI TKLDLMDEGT DARDVLENKL LPLRRGYVGV VNRSQKDIDG KKDIKAAMLA
     ERKFFLSHPA YRHIADRMGT PHLQKVLNQQ LTNHIRDTLP NFRNKLQGQL LSIEHEVEAY
     KNFKPEDPTR KTKALLQMVQ QFAVDFEKRI EGSGDQVDTL ELSGGAKINR IFHERFPFEI
     VKMEFNEKEL RREISYAIKN IHGIRTGLFT PDMAFEAIVK KQIVKLKGPS LKSVDLVMQE
     LINTVKKCTK KLANFPRLCE ETERIVANHI REREGKTKDQ VLLLIDIQVS YINTNHEDFI
     GFANAQQRSS QVHKKTTIGN QVIRKGWLTI SNIGIMKGGS KGYWFVLTAE SLSWYKDDEE
     KEKKYMLPLD NLKVRDVEKS FMSSKHIFAL FNTEQRNVYK DYRFLELACD SQEDVDSWKA
     SLLRAGVYPD KSLTENDENG QTENFSMDPQ LERQVKDFIN SELLAQLYSS EDQNTLMEES
     AEQAQRRDEM LRMYQALKEA LVIIGDINTA TVSTPAPPPV DDSWIQHSRR SPPPSPTTQR
     RPTLSTPLTR PTSGRGPAPA IPSPGPHSGA PPVPFRPGPL PPFPNSSDSF GAPPQVPSRP
     TRAPPSVPSR RPPPSPTRPT IIRPLESSLL D
//
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