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Database: UniProt
Entry: H0UVG5_CAVPO
LinkDB: H0UVG5_CAVPO
Original site: H0UVG5_CAVPO 
ID   H0UVG5_CAVPO            Unreviewed;       856 AA.
AC   H0UVG5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-SEP-2017, entry version 33.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSCPOP00000001001};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001001};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000001001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001001};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000001001}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001001};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000001001}.
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DR   EMBL; AAKN02052322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005000488.1; XM_005000431.2.
DR   STRING; 10141.ENSCPOP00000001001; -.
DR   Ensembl; ENSCPOT00000001117; ENSCPOP00000001001; ENSCPOG00000001106.
DR   GeneID; 101787762; -.
DR   CTD; 23545; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H0UVG5; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000001106; -.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    468       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    584    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    651    674       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    784    807       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   856 AA;  97648 MW;  7237B2D4A7EFFD80 CRC64;
     MGSLFRSEPM CLAQLFLQAG TAYECLSALG ERGLVQFRDL NQNVSSFQRK FVGEVKRCEE
     LERILVYLAQ EITKADIPLS EGEVSPLAPP LKQVLEMQEQ LQKLEVELRE VTKNKEKLRK
     NLLELIEYTH MLRVTRTFVK RNMEFEPTYE EFPSLENECL LDYSYMQRLG AKLGFVSGLI
     QQGKVEAFER MLWRVCKGYT IVTYAELDES LEDPETGEII KWYVFLISFW GEQIGQKVKK
     ICDCYHCHVY PYPSTAEERK EIQEGLSTRI QDLYTVLHRT EDYLRQVLCK AAESVSSRAV
     QVRKMKAIYH TLNMCSFDVT NKCLIAEVWC PEADLHELRR ALEEGSRESG AAMPSFLNTI
     STKETPPTLI RTNRFTEGFQ SIVDAYGVGS YREVNPALFT IITFPFLFAV MFGDFGHGFV
     MFLFALLLVL KEDHPRLTQS QEILRMFFNG RYILLLMGLF SVYTGLIYND CFSKSVNLFG
     SGWNVSAMYS AGPASEERSG LALWNASTVR HSRVLQLDPS VPGVFRGPYP FGIDPIWNLA
     TNRLTFLNSF KMKMSVILGI THMTFGVILG IFNHMHFRKK FNIYLVSIPE LLFMLCIFGY
     LIFMIIYKWL AYSAATSREA PSILIDFINM FLFPANEASG LYPGQAYVQR VLLAITVLSV
     PILFLGKPLF LLWLHHGRGC FGVSRSGYTL VRRDSEEEVS LLGNQDIEEG SNQEARCREV
     TCEEFNFGEI LMTQAIHSIE YCLGCVSNTA SYLRLWALSL AHAQLSDVLW AMVMRVGLRV
     DTTLGVLLLF LVIAVFTVLT VFILLVMEGL SAFLHAIRLH WVEFQNKFYV GAGTKFVPFS
     FSLLLSSKFS DDNGAM
//
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