ID H0UWV9_CAVPO Unreviewed; 412 AA.
AC H0UWV9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Docking protein 2 {ECO:0000313|Ensembl:ENSCPOP00000001557.2};
GN Name=DOK2 {ECO:0000313|Ensembl:ENSCPOP00000001557.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001557.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000001557.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001557.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type A subfamily.
CC {ECO:0000256|ARBA:ARBA00010955}.
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DR EMBL; AAKN02003245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479698.1; XM_003479650.3.
DR AlphaFoldDB; H0UWV9; -.
DR STRING; 10141.ENSCPOP00000001557; -.
DR Ensembl; ENSCPOT00000001747.3; ENSCPOP00000001557.2; ENSCPOG00000001726.4.
DR GeneID; 100725807; -.
DR KEGG; cpoc:100725807; -.
DR CTD; 9046; -.
DR VEuPathDB; HostDB:ENSCPOG00000001726; -.
DR eggNOG; KOG4047; Eukaryota.
DR GeneTree; ENSGT00940000159868; -.
DR HOGENOM; CLU_030101_2_0_1; -.
DR InParanoid; H0UWV9; -.
DR OMA; YDSIEDH; -.
DR OrthoDB; 2996885at2759; -.
DR TreeFam; TF324994; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001726; Expressed in thyroid gland and 12 other cell types or tissues.
DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037751; Dok1/2/3_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF14; DOCKING PROTEIN 2; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 7..117
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 150..255
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 252..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..283
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45479 MW; 7E8EEF50CD9C8CB3 CRC64;
MVRMEEVAVK QGSLHLQQQQ TFGKKWRRFS AVLYGESGSA LARLELHEGP EKLRRGEAAR
KVIRLSDCLR VVEGGGEASS PRDTSAFILE TKERLYLLAA PSAERDDWMQ AICLLAFPGQ
KKESLGPDEK DSWPHMEENE LYSSSVTGVS CKQFAVTIRP TEASERCRLR GTYTLRAGVS
ALELWAGSEP GTQLYDWPYR FLRRFGRDKV TFSFEAGRRC VSGEGNFEFE TRQGNEIFLA
LEQAIAAQKD ATPPVPSLVP ATVPTVPTEL PRPESPYSQP HDLLPPQPLA SARAQPGLRP
PESEYAVPFD AVARSLSKSL QSILASPSPL SADPFYDSIE EAKAPVPDHI YDEPEGVATL
SLYDIPQESP GQAWRRKATV DGGPSDSQKD CSVLGWPQGT EYDNVVLKKG SK
//
