ID H0UYH2_CAVPO Unreviewed; 1454 AA.
AC H0UYH2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Myomesin 2 {ECO:0000313|Ensembl:ENSCPOP00000002185.3};
GN Name=MYOM2 {ECO:0000313|Ensembl:ENSCPOP00000002185.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002185.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002185.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002185.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02003398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000002185; -.
DR Ensembl; ENSCPOT00000002435.3; ENSCPOP00000002185.3; ENSCPOG00000002402.4.
DR VEuPathDB; HostDB:ENSCPOG00000002402; -.
DR eggNOG; ENOG502QS6D; Eukaryota.
DR GeneTree; ENSGT00940000157057; -.
DR HOGENOM; CLU_004753_1_0_1; -.
DR InParanoid; H0UYH2; -.
DR OMA; ASFRFVI; -.
DR TreeFam; TF331825; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002402; Expressed in heart left ventricle and 2 other cell types or tissues.
DR GO; GO:0031430; C:M band; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 2.
DR CDD; cd05891; IgI_M-protein_C; 1.
DR CDD; cd20951; IgI_titin_I1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR13817:SF73; PROTEIN SIDEKICK HOMOLOG; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 159..250
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 271..359
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..485
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 518..613
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 619..712
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 715..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 820..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 909..1007
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1135..1216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1347..1423
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 36..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1454 AA; 164031 MW; 3AD4362D6211E2A5 CRC64;
MYLVALPFYQ KRHKHFDQSY RHIQTRYLLD EYASKKRTSS QSSTQRALTQ MSSAQRVSSQ
TSTQRALTQT LSAQKARAAS MSTGEKQQED EHRYQSLEAA YGEAKRQRFL SELAQLEQDV
HLVRSHARDT LDKYTLQKTV EDQMAWERHV FEERMSRAPE ILVRLRSHTV WEKMSVQLCF
TVQGFPTPVV QWYKDGNLIC QASEPGKYLI ESKYGVHTLQ INRADFDDTA TYSAVATNIH
GQVSTNAAVV VKRFRGEEEP FHSVGLPIGL PLSLVIPYTH FDVQFLEKFG VTFRREGETL
TLKCTMLVTP DLKRVQPRAE WYRDDVLLQE SKWTKMFFGE GQASLSFSHL NKDDEGLYTL
RIVSRGGVSD HSAFLFVRDA DPLVTGAPGA PMDLECHDAN RDYVILTWKP PNTTMESPVI
GYFIDRCEVG TDSWVQCNDS PVKICKYPVT GLIEGRSYLF RVRAINSAGV SRPSRVSAAV
AALDPTDLRR LQAIHLEGDK EIVIYKDDLE GDIQIPGPPT NVHASEISRT YVVLSWEPPT
PRGKEPLVYF IEKSVVGSGT WQRVNAQMAV RSPRYAVFDL ADGKSYVFRV LSANKHGLSD
PSEITSPIQA QDTIVVPSSP GRVLASRNTK TSVVVQWDRP KHEEDLLGYY VDCCVAGTNQ
WEPCNHKPIG YNRFVVHGLT TGEQYIFRVK AVNPVGTSEN SQESDVIKVQ AALTVPSYPY
GITLLNCDGH SMTLGWKVPK FSGGAPILGY YVDKREAQHR NWHEVNASPL QDRILTVEGL
TEGSLYEFKI TATNLAGIGQ PSDPSELFKC EAWTAPEPGP AYDLTFCEVR DTSLVLLWKA
PVYSGSSPVS GYFVDFKEVD SGEWKTVNEA TSPNRYLKVC DLQKGQTYVF RVRAVNASGP
GKPSDMSEPV LVEARPGTKE ISAGVDDEGN IYLSFDCQEM TDASQFTWCK SYEEIADEDR
FRVHTEGDRS RLYFKTPDKV DVGTYSVSVS DTEGVSSSFV LDEEELERLM ALSNEIKNPT
IPLKSELAYE ILEKGQVRFW LQAEHLSPDA DFRFVINDRE VSDSETHRIK CDKSTGLIEM
VMDRFTIENE GSYTVQIHDG KAKNQSSLIL IGDAFKAILE EAEFQRKEFL RKQGPHFAEY
LHWDVTEECE VRLVCKVANT KKETVFKWLK DDVLYETETP PDLEKGVCEL FIPKLSRKDH
GEYKATLKDD RGQDISILEI AGKAFSWSSA GISASPLKIL CTPEGIRLQC FMKYFTEEMK
VNWYHKEAKI SSSEHMRVGG SEEMAWLQIC EPTEKDKGKY TFEIFDGKDN HHRSLDLSGQ
AFDEAFEEFQ HRGKVIGGLP DVVTIMEGKT LNLTCTVFGN PDPEVVWFKN DKDIELSEHF
SVKVEQAKYV SLTITKVTSE DSGKYSIHVR NKYGGEKIDV TVSVYKHGEK IPDIVPPQQA
KPKLIPASTS ASAE
//
