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Database: UniProt
Entry: H0V0A1_CAVPO
LinkDB: H0V0A1_CAVPO
Original site: H0V0A1_CAVPO 
ID   H0V0A1_CAVPO            Unreviewed;       759 AA.
AC   H0V0A1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 73.
DE   SubName: Full=Sortilin 1 {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
GN   Name=SORT1 {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002884.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000002884.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AAKN02004525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02004526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0V0A1; -.
DR   STRING; 10141.ENSCPOP00000002884; -.
DR   Ensembl; ENSCPOT00000003227.3; ENSCPOP00000002884.3; ENSCPOG00000003184.4.
DR   VEuPathDB; HostDB:ENSCPOG00000003184; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   GeneTree; ENSGT01030000234563; -.
DR   HOGENOM; CLU_013596_0_0_1; -.
DR   InParanoid; H0V0A1; -.
DR   OMA; KNKINFW; -.
DR   TreeFam; TF324918; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000003184; Expressed in testis and 12 other cell types or tissues.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0048406; F:nerve growth factor binding; IEA:Ensembl.
DR   GO; GO:0010465; F:nerve growth factor receptor activity; IEA:Ensembl.
DR   GO; GO:0030379; F:neurotensin receptor activity, non-G protein-coupled; IEA:Ensembl.
DR   GO; GO:1905394; F:retromer complex binding; IEA:Ensembl.
DR   GO; GO:0006897; P:endocytosis; IEA:Ensembl.
DR   GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:0046323; P:glucose import; IEA:Ensembl.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:Ensembl.
DR   GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR   GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR   GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR   GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
DR   GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR   GO; GO:0006622; P:protein targeting to lysosome; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   GO; GO:0016050; P:vesicle organization; IEA:Ensembl.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106:SF23; SORTILIN; 1.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   DOMAIN          31..643
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
FT   REGION          642..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..657
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  84627 MW;  494FC82CD3BEBEA6 CRC64;
     HVFDDLSGSV SLSWVGDRTG VILVLTTFHV PLVIMTFGQS KLYRSEDYGK NFKDITNLIN
     NTFIRTEFGM AIGPENSGKV ILTAEVSGGS HGGRIFRSSD FAKNFVQTDL PFHPLTQMMY
     SPHNSDYLLA LSTENGLWVS KNFGGKWKEI HKAVCLAKWG SGNIIFFTTY VNGSCKADLG
     ALELWRTSDL GKTFKTIGMK IYSFGLGGRF LFASVMADKD TTRRIHVSTD QGDTWSMAQL
     PSVGQEQFYS ILAANDDMVF MHVDEPGDTG FGTIFTSDDR GIVYSKSLDR HLYTTTGGET
     DFTNVTSLRG VYITSMLSED NSIQTMITFD QGGRWKHLRK PENSECDATA KNKNECSLHI
     HASYSISQKL NVPMAPLTEP NAVGIVIAHG SVGDAISVMV PDVYISDDGG YSWMKMLEGP
     HYYTILDSGG IIVAIEHSNH PINVIKFSTD EGQCWQTYMF TREPIYFTGL ASEPGARSMN
     ISIWGFTESF LTRQWVSYTI DFKDILERNC EEKDYTIWLA HSTDPGDYED GCILGYREQY
     LRLRKSSVCQ NGRDYVVTKQ PSICPCSLED FLCDFGYFRP ENDSKCVEQP ELKGHDLEFC
     LYGREEHLTT NGYRKIPGDR CQGGVNPARE VKDLKKKCTS NFLSPKKQDS RPQGHSLSQN
     PAPPPLGHIE NTHFLSPTQK QNSKSNSVPI ILAIVGLMLV TVVAGVLLVK KYVCGGRFLV
     HRYSVLQQHA EADGVDALDT ASHANKSGYH DDSDEDLLE
//
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