ID H0V0A1_CAVPO Unreviewed; 759 AA.
AC H0V0A1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Sortilin 1 {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
GN Name=SORT1 {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000002884.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000002884.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000002884.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAKN02004525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02004526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V0A1; -.
DR STRING; 10141.ENSCPOP00000002884; -.
DR Ensembl; ENSCPOT00000003227.3; ENSCPOP00000002884.3; ENSCPOG00000003184.4.
DR VEuPathDB; HostDB:ENSCPOG00000003184; -.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_013596_0_0_1; -.
DR InParanoid; H0V0A1; -.
DR OMA; KNKINFW; -.
DR TreeFam; TF324918; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003184; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0048406; F:nerve growth factor binding; IEA:Ensembl.
DR GO; GO:0010465; F:nerve growth factor receptor activity; IEA:Ensembl.
DR GO; GO:0030379; F:neurotensin receptor activity, non-G protein-coupled; IEA:Ensembl.
DR GO; GO:1905394; F:retromer complex binding; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0046323; P:glucose import; IEA:Ensembl.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:Ensembl.
DR GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR GO; GO:0006622; P:protein targeting to lysosome; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR GO; GO:0016050; P:vesicle organization; IEA:Ensembl.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106:SF23; SORTILIN; 1.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 31..643
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 642..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 84627 MW; 494FC82CD3BEBEA6 CRC64;
HVFDDLSGSV SLSWVGDRTG VILVLTTFHV PLVIMTFGQS KLYRSEDYGK NFKDITNLIN
NTFIRTEFGM AIGPENSGKV ILTAEVSGGS HGGRIFRSSD FAKNFVQTDL PFHPLTQMMY
SPHNSDYLLA LSTENGLWVS KNFGGKWKEI HKAVCLAKWG SGNIIFFTTY VNGSCKADLG
ALELWRTSDL GKTFKTIGMK IYSFGLGGRF LFASVMADKD TTRRIHVSTD QGDTWSMAQL
PSVGQEQFYS ILAANDDMVF MHVDEPGDTG FGTIFTSDDR GIVYSKSLDR HLYTTTGGET
DFTNVTSLRG VYITSMLSED NSIQTMITFD QGGRWKHLRK PENSECDATA KNKNECSLHI
HASYSISQKL NVPMAPLTEP NAVGIVIAHG SVGDAISVMV PDVYISDDGG YSWMKMLEGP
HYYTILDSGG IIVAIEHSNH PINVIKFSTD EGQCWQTYMF TREPIYFTGL ASEPGARSMN
ISIWGFTESF LTRQWVSYTI DFKDILERNC EEKDYTIWLA HSTDPGDYED GCILGYREQY
LRLRKSSVCQ NGRDYVVTKQ PSICPCSLED FLCDFGYFRP ENDSKCVEQP ELKGHDLEFC
LYGREEHLTT NGYRKIPGDR CQGGVNPARE VKDLKKKCTS NFLSPKKQDS RPQGHSLSQN
PAPPPLGHIE NTHFLSPTQK QNSKSNSVPI ILAIVGLMLV TVVAGVLLVK KYVCGGRFLV
HRYSVLQQHA EADGVDALDT ASHANKSGYH DDSDEDLLE
//