ID H0V122_CAVPO Unreviewed; 870 AA.
AC H0V122;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Synuclein alpha interacting protein {ECO:0000313|Ensembl:ENSCPOP00000003179.3};
GN Name=SNCAIP {ECO:0000313|Ensembl:ENSCPOP00000003179.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003179.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003179.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003179.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02010269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V122; -.
DR Ensembl; ENSCPOT00000003561.3; ENSCPOP00000003179.3; ENSCPOG00000003517.4.
DR VEuPathDB; HostDB:ENSCPOG00000003517; -.
DR GeneTree; ENSGT00390000001485; -.
DR HOGENOM; CLU_012404_0_0_1; -.
DR TreeFam; TF329095; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003517; Expressed in ovary and 13 other cell types or tissues.
DR Gene3D; 6.10.250.750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040133; SNCAIP.
DR InterPro; IPR032027; SNCAIP_SNCA-bd.
DR PANTHER; PTHR22882; SYNPHILIN-1; 1.
DR PANTHER; PTHR22882:SF3; SYNPHILIN-1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16700; SNCAIP_SNCA_bd; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REPEAT 395..427
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 451..492
FT /note="Synphilin-1 alpha-Synuclein-binding"
FT /evidence="ECO:0000259|Pfam:PF16700"
FT REGION 78..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 461..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 80..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 95247 MW; BC01725822D8955D CRC64;
MEAPEYLDLD EIDFSDDISY SVTSLKTIPE LCRRCDSQNE DRAVSSSGWN CGISTLLTNT
QKPTGIADVY SKFRPVKRVS PLKHQPETLE NNESDDQKNH KGEYQKGGES DQGPQAEELS
PEDGGGSVPG KSSEPSSALG ELEHYDLDMD EILDVPYIKS SQQLASFTKA PSEKRILGLC
TTLNGLPGKA CSPGSSENSP STMTPFCILS PVKSPPSRKA PAVFRDPHKL LTEAAENSPP
SGKCVPAYAP ENQNKGFLNK AFSDPHDRKM EKTAPDCHLR AFHSQSSASE PNLEEQVSGT
AWTSSQGPEE RNEHLKKVKS ILNIVKEGQI SLLNGQLECV RWMVSETEAI AELSCSKDFP
SLIHYAGCYG QEKILLWLLQ FMQEQGISLD EVDYEGNSAV HVASQHGYLG CIQTLVEYGA
NVTMQNHAGE KPSQSAERHG HTLCSRYLVV VETCMSLASQ VVKLTKQLKE QTMERVTLQN
QLQQLLEAQK SEDKSLPSLP SSPASRKSHW KVPDASDESV AKSKPGVQEG IQVLGSLSAS
SRVRAKAKDE DSDKILRQLL GKEISENVCT QEKLTLEFQD AQACSRNPKK IPLEKRELKL
ARLRQLMQRS LSESDTDSNN SEDPKNTPVR KADRPRPQPI VESVENMDST ESLHLMIKKH
SLASGRRFPF STKASKSLDG HSPSPTSENS EPDLESQCLG LGSIPPSQPS GDPTQSNPDS
AAAQKVATSP KSALKSPSSK RRTSQNLKLR VTFEEPVVQM EPSSVLELDG DKDKDRDKGR
TLPRNSTSSE SGEQLKRPFG TFRSIMESLS GNQNNNNNCP AASQLKTSTL PLTSLGRKTA
DNKGNPVSSA SKGKSKAVSA LWRISFFFLG
//