ID H0V154_CAVPO Unreviewed; 560 AA.
AC H0V154;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Tudor and KH domain containing {ECO:0000313|Ensembl:ENSCPOP00000003213.2};
GN Name=TDRKH {ECO:0000313|Ensembl:ENSCPOP00000003213.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003213.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003213.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003213.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02003953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012998619.1; XM_013143165.1.
DR STRING; 10141.ENSCPOP00000022709; -.
DR Ensembl; ENSCPOT00000003600.3; ENSCPOP00000003213.2; ENSCPOG00000003556.4.
DR Ensembl; ENSCPOT00000037802.1; ENSCPOP00000022709.1; ENSCPOG00000003556.4.
DR GeneID; 100714350; -.
DR KEGG; cpoc:100714350; -.
DR CTD; 11022; -.
DR VEuPathDB; HostDB:ENSCPOG00000003556; -.
DR eggNOG; KOG2279; Eukaryota.
DR GeneTree; ENSGT00940000159364; -.
DR HOGENOM; CLU_023629_1_0_1; -.
DR OMA; NMVQEMT; -.
DR OrthoDB; 375531at2759; -.
DR TreeFam; TF318292; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003556; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0071546; C:pi-body; IEA:Ensembl.
DR GO; GO:0071547; C:piP-body; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0034587; P:piRNA processing; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd22428; KH-I_TDRKH_rpt1; 1.
DR CDD; cd22429; KH-I_TDRKH_rpt2; 1.
DR CDD; cd20412; Tudor_TDRD2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR047382; KH-I_TDRKH_rpt1.
DR InterPro; IPR047381; KH-I_TDRKH_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR047380; TDRD2-like_tudor.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR22948:SF18; TUDOR AND KH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 352..411
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 208..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 61815 MW; 35007A211018E78A CRC64;
MSTERTSWTS LSTIQKVALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP
QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDIGDERVLL ISGFPVQVCK AKAAIHQILT
ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLVKISGTQ
KEVAAAKHLI LEKVSEDEEL RKRIAHSAEA RVPRKQPISV RREERTESGG AGEPAVWKNG
SSDSKQAAPL AVPRRKGGGD LAVGGPREGS WEEPNNSFQK TEVQTSPEKS IFEIPSPDFS
FHADEYLEVY VSASEHPNHF WIQIIGSRSL QLDKLVSEMT QHYESSPPED LTVHVGDIVA
APLSTNGSWY RARVLGTLEN GNLDLYFVDF GDNGDCPLKN LRALRSDFLS LPFQAIECSL
ARIAPSGEQW EEEALDEFDR LTYCADWKPL VAKISSYVQT GVSTWPKIYL YDTSNGKKLD
IGLELVRKGY AIELPEDMEE NGTVPDMLKD MATETDASPA SMLTEPKKSP GEMAHTLSCL
SLSEAASMSG DDNLEDDYLL
//
